{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T19:23:40Z","timestamp":1766690620670},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The aim of the study was to identify all patients who presented with oesophagogastric malignancy within a single National Health Service region (Wales) over 1 year, and to follow the cohort for 5 years. Management and outcome were analysed to identify current practice and draft guidelines for Wales.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients were identified from hospital records. Details were recorded in structured format for analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Analysable data were obtained for 910 of 916 patients. The overall incidence was 31\u00b74 per 100 000 population. Treatment was by resection 298 (33 per cent), palliation 397 (44 per cent) or no treatment 215 (24 per cent). The 30-day mortality rate was 12 per cent and the in-hospital mortality rate was 13 per cent. Some 226 patients (25 per cent) were alive at 2 years. Resection conferred a significant survival advantage over palliation (P &amp;lt; 0\u00b7001) and no treatment. Anastomotic leakage occurred in 16 patients (5 per cent), of whom eight died in hospital. \u2018Open and close\u2019 operations were common (23 per cent), laparoscopy was infrequent (16 per cent), and many surgeons undertook small caseloads. Operating on fewer than six patients per year increased the mortality rate after partial gastrectomy (P &amp;lt; 0\u00b705) and was associated with a trend to a higher mortality rate after mediastinal and cardia surgery. Operating on more than 70 per cent of patients seen resulted in a significantly higher mortality rate (P &amp;lt; 0\u00b701) irrespective of case volume.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Tumour resection conferred a survival advantage. Wider use of laparoscopy is advocated. Improved selection for surgery should result in a lower mortality rate.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1046\/j.1365-2168.2001.01655.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T07:21:07Z","timestamp":1047367267000},"page":"278-285","source":"Crossref","is-referenced-by-count":56,"title":["One-year survey of carcinoma of the oesophagus and stomach in Wales"],"prefix":"10.1093","volume":"88","author":[{"given":"J K","family":"Pye","sequence":"first","affiliation":[{"name":"Wrexham Maelor Hospital , Wrexham,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M K H","family":"Crumplin","sequence":"additional","affiliation":[{"name":"Wrexham Maelor Hospital , Wrexham,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Charles","sequence":"additional","affiliation":[{"name":"North Wales Health Authority , Mold,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Kerwat","sequence":"additional","affiliation":[{"name":"Wrexham Maelor Hospital , Wrexham,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M E","family":"Foster","sequence":"additional","affiliation":[{"name":"East Glamorgan Hospital , Pontypridd,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Biffin","sequence":"additional","affiliation":[{"name":"All Wales Audit and Research Unit, Llandough Hospital , Penarth,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,2,1]]},"reference":[{"volume-title":"Mortality Statistics Cause, 1981\u20131990","year":"1991","author":"Office of Population Censuses and Surveys","key":"2024093006060481700_bib1"},{"key":"2024093006060481700_bib2","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1001\/jama.1991.03460100089030","article-title":"Rising incidence of adenocarcinoma of the esophagus and gastric cardia","volume":"265","author":"Blot","year":"1991","journal-title":"JAMA"},{"key":"2024093006060481700_bib3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/00008469-199204000-00008","article-title":"The rising trend in oesophageal adenocarcinoma and gastric cardia","volume":"1","author":"Powell","year":"1992","journal-title":"Eur J Cancer Prev"},{"key":"2024093006060481700_bib4","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1002\/bjs.1800791226","article-title":"Oesophageal cancer: a population-based study of survival after treatment","volume":"79","author":"Oliver","year":"1992","journal-title":"Br J Surg"},{"key":"2024093006060481700_bib5","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/bjs.1800770804","article-title":"Surgical therapy of oesophageal carcinoma","volume":"77","author":"Muller","year":"1990","journal-title":"Br J Surg"},{"key":"2024093006060481700_bib6","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/bjs.1800670602","article-title":"Oesophageal squamous cell carcinoma 1. 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