{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:23:20Z","timestamp":1767666200516},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2001,3,1]],"date-time":"2001-03-01T00:00:00Z","timestamp":983404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Lung transplantation is widely accepted as a treatment for end-stage lung disease. At present, information regarding the incidence and outcome of acute gastrointestinal complications in lung transplant survivors is limited.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Since 1990, 127 lung transplantations have been performed in 125 patients: 73 males (58 per cent) and 52 females (42 per cent) of median age 43 (range 9\u201364) years. Patients received a standard induction and maintenance regimen of immunosuppression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>At a median follow-up of 2\u00b76 (range 0\u20138\u00b76) years the overall survival rate was 68 per cent. An acute abdomen requiring surgical intervention was diagnosed in 12 patients (10 per cent). The median time following lung transplantation was 19 (range 3\u201368) months. Eight cases of bowel perforation, two of appendicitis, one of colitis, one of cholecystitis, and one pneumoperitoneum were encountered. Four Hartmann procedures, two sigmoid resections, one small bowel resection, two appendicectomies, a subtotal colectomy, a cholecystectomy and an exploratory laparotomy were performed with minimal morbidity and no postoperative death.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Lung transplant survivors are at increased risk of developing an acute abdomen because of the use of high-dose immunosuppressive agents. Physicians who evaluate lung transplant patients for an acute abdomen should have a low threshold for surgical intervention.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1046\/j.1365-2168.2001.01693.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T07:21:13Z","timestamp":1047367273000},"page":"433-438","source":"Crossref","is-referenced-by-count":44,"title":["Gastrointestinal complications in lung transplant survivors that require surgical intervention"],"prefix":"10.1093","volume":"88","author":[{"given":"H J","family":"Hoekstra","sequence":"first","affiliation":[{"name":"Department of Surgery, Groningen University Hospital , Groningen,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Department of Surgery, Groningen University Hospital , Groningen,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W J","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Groningen University Hospital , Groningen,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Rottier","sequence":"additional","affiliation":[{"name":"Department of Surgery, Groningen University Hospital , Groningen,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"van der Bij","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Groningen University Hospital , Groningen,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,3,1]]},"reference":[{"key":"2024093006214069400_bib1","first-page":"656","article-title":"The Registry of the International Society for Heart and Lung Transplantation: fifteenth official report \u2013 1998","volume":"17","author":"Hosenpud","year":"1998","journal-title":"J Heart Lung Transplant"},{"key":"2024093006214069400_bib2","first-page":"547","article-title":"Gastrointestinal complications in heart and in heart\u2013lung transplant patients","volume":"10","author":"Augustine","year":"1991","journal-title":"J Heart Lung Transplant"},{"key":"2024093006214069400_bib3","first-page":"412","article-title":"Gastrointestinal complications after cardiac transplantation: a spectrum of diseases","volume":"86","author":"Cates","year":"1991","journal-title":"Am J Gastroenterol"},{"key":"2024093006214069400_bib4","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1097\/00000658-199005000-00003","article-title":"Gastrointestinal complications after cardiac transplantation. Potential benefit of early diagnosis and prompt surgical intervention","volume":"211","author":"Kirklin","year":"1990","journal-title":"Ann Surg"},{"key":"2024093006214069400_bib5","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1001\/archsurg.1989.01410080019002","article-title":"Major abdominal complications following cardiac transplantation. Utah Transplantation Affiliated Hospitals Cardiac Transplant Program","volume":"124","author":"Merrell","year":"1989","journal-title":"Arch Surg"},{"key":"2024093006214069400_bib6","first-page":"3745","article-title":"Gastrointestinal complications and appendicitis after kidney transplantation","volume":"21","author":"Santiago-Delpin","year":"1989","journal-title":"Transplant Proc"},{"key":"2024093006214069400_bib7","first-page":"244","article-title":"Gastrointestinal complications and endoscopic findings in heart transplant patients","volume":"12","author":"Steck","year":"1993","journal-title":"J Heart Lung Transplant"},{"key":"2024093006214069400_bib8","first-page":"739","article-title":"General surgical complications in heart and heart\u2013lung transplantation","volume":"98","author":"Steed","year":"1985","journal-title":"Surgery"},{"key":"2024093006214069400_bib9","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/bjs.1800780622","article-title":"Early abdominal complications following heart and heart\u2013lung transplantation","volume":"78","author":"Watson","year":"1991","journal-title":"Br J Surg"},{"key":"2024093006214069400_bib10","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0003-4975(96)00393-1","article-title":"Colon perforation after lung transplantation","volume":"62","author":"Beaver","year":"1996","journal-title":"Ann Thorac Surg"},{"key":"2024093006214069400_bib11","first-page":"681","article-title":"Sigmoid diverticular perforation complicating lung transplantation","volume":"16","author":"Fenton","year":"1997","journal-title":"J Heart Lung Transplant"},{"key":"2024093006214069400_bib12","first-page":"2382","article-title":"Gastrointestinal complications after orthotopic lung transplantation","volume":"91","author":"Lubetkin","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"2024093006214069400_bib13","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1001\/archsurg.1997.01430310028004","article-title":"Abdominal operations after lung transplantation. Indications and outcome","volume":"132","author":"Pollard","year":"1997","journal-title":"Arch Surg"},{"key":"2024093006214069400_bib14","first-page":"44","article-title":"Abdominal complications after lung transplantation","volume":"14","author":"Smith","year":"1995","journal-title":"J Heart Lung Transplant"},{"key":"2024093006214069400_bib15","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/S1010-7940(97)00231-5","article-title":"Incidence and outcome of major non-pulmonary surgical procedures in lung transplant recipients","volume":"12","author":"Wekerle","year":"1997","journal-title":"Eur J Cardiothorac Surg"},{"key":"2024093006214069400_bib16","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/0002-9610(71)90076-6","article-title":"Acute perforation of colonic diverticula associated with prolonged adrenocorticosteroid therapy","volume":"121","author":"Canter","year":"1971","journal-title":"Am J Surg"},{"key":"2024093006214069400_bib17","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/00000658-198010000-00016","article-title":"Bowel perforation in steroid-treated patients","volume":"192","author":"Remine","year":"1980","journal-title":"Ann Surg"},{"key":"2024093006214069400_bib18","first-page":"56","article-title":"Colon perforations associated with steroid therapy","volume":"75","author":"Sterioff","year":"1974","journal-title":"Surgery"},{"key":"2024093006214069400_bib19","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1001\/archsurg.1991.01410310065009","article-title":"Acute diverticulitis. A complicated problem in the immuno-compromised patient","volume":"126","author":"Tyau","year":"1991","journal-title":"Arch Surg"},{"key":"2024093006214069400_bib20","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/0002-9610(76)90154-9","article-title":"Acute perforation of the colon associated with chronic corticosteroid therapy","volume":"131","author":"Warshaw","year":"1976","journal-title":"Am J Surg"},{"key":"2024093006214069400_bib21","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1378\/chest.105.3.929","article-title":"Pneumatosis intestinalis and active cytomegaloviral infection after lung transplantantion. Groningen Lung Transplant Group","volume":"105","author":"Mannes","year":"1994","journal-title":"Chest"},{"key":"2024093006214069400_bib22","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1200\/JCO.1995.13.4.961","article-title":"Lymphoproliferative disorders after organ trans-plantation: a report of 24 cases observed in a single center","volume":"13","author":"Leblond","year":"1995","journal-title":"J Clin Oncol"},{"key":"2024093006214069400_bib23","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/17401","article-title":"Cyclosporine induces cancer progression by a cell-autonomous mechanism","volume":"397","author":"Hojo","year":"1999","journal-title":"Nature"},{"key":"2024093006214069400_bib24","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/S0041-1345(98)00343-1","article-title":"Prevalence of malignancies after lung transplantation","volume":"30","author":"Spiekerkoetter","year":"1998","journal-title":"Transplant Proc"},{"key":"2024093006214069400_bib25","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1097\/00007890-198711000-00023","article-title":"Acute appendicitis in the renal allograft recipient","volume":"44","author":"Roza","year":"1987","journal-title":"Transplantation"},{"key":"2024093006214069400_bib26","first-page":"4149","article-title":"Cyclosporine-induced cholestasis: inhibition of bile acid secretion is caused by the parental molecule","volume":"19","author":"Le Thai","year":"1987","journal-title":"Transplant Proc"},{"key":"2024093006214069400_bib27","first-page":"623","article-title":"Management of biliary complications after heart transplantation","volume":"14","author":"Peterseim","year":"1995","journal-title":"J Heart Lung Transplant"},{"key":"2024093006214069400_bib28","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0272-5231(05)70385-3","article-title":"Nonpulmonary medical complications in the intermediate and long-term survivor","volume":"18","author":"Maurer","year":"1997","journal-title":"Clin Chest Med"},{"key":"2024093006214069400_bib29","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/BF00294752","article-title":"Optimal timing and indications for chole-cystectomy in cardiac transplant patients","volume":"19","author":"Begos","year":"1995","journal-title":"World J Surg"},{"key":"2024093006214069400_bib30","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1001\/archsurg.133.1.73","article-title":"Cholecystectomy in cardiothoracic organ transplant recipients","volume":"133","author":"Lord","year":"1998","journal-title":"Arch Surg"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2168.2001.01693.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2168.2001.01693.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/88\/3\/433\/59441502\/bjs357.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/88\/3\/433\/59441502\/bjs357.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T06:26:18Z","timestamp":1727677578000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/88\/3\/433\/6268108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3,1]]},"references-count":30,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2001,3,1]]},"published-print":{"date-parts":[[2001,3,1]]}},"URL":"https:\/\/doi.org\/10.1046\/j.1365-2168.2001.01693.x","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"type":"print","value":"0007-1323"},{"type":"electronic","value":"1365-2168"}],"subject":[],"published-other":{"date-parts":[[2001,3]]},"published":{"date-parts":[[2001,3,1]]}}}