{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T18:22:29Z","timestamp":1759602149607},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2002,7,1]],"date-time":"2002-07-01T00:00:00Z","timestamp":1025481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,11,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The prognosis of patients without nodal metastasis of oesophageal cancer is generally good, but recurrence develops in some cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data on 88 consecutive patients with squamous oesophageal cancer who underwent three-field lymph node dissection from 1986 to September 1998 and who had no evidence of nodal disease were reviewed retrospectively. Disease status was based on histological examination of the section of each node with the largest surface area, stained with haematoxylin and eosin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The 3- and 5-year survival rates of patients without lymph node metastasis were 85 and 81 per cent respectively, better than in patients with metastasis. Twelve patients died from recurrence. Recurrence was haematogenous in nine patients and locoregional in three. Survival was worse in men, for patients with lesions located in the upper thoracic oesophagus, and in those with lymphatic or blood vessel invasion. Only the presence of lymphatic invasion correlated with survival on multivariate analysis (P = 0\u00b704).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Although survival was generally good in patients without nodal metastasis from oesophageal cancer following three-field lymph node dissection, patients with lymphatic invasion remained at risk for haematogenous dissemination.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1046\/j.1365-2168.2002.02109.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T07:29:09Z","timestamp":1047367749000},"page":"909-913","source":"Crossref","is-referenced-by-count":33,"title":["Prognostic factors after oesophagectomy and extended lymphadenectomy for squamous oesophageal cancer"],"prefix":"10.1093","volume":"89","author":[{"given":"H","family":"Osugi","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery, Osaka City University Medical School, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Takemura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Osaka City University Medical School, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Osaka City University Medical School, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Hirohashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Osaka City University Medical School, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Osaka City University Medical School, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Higashino","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Osaka City University Medical School, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,11,5]]},"reference":[{"key":"2021070907202908000_bib1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/00000658-198110000-00007","article-title":"Principles of surgical treatment for carcinoma of the esophagus: analysis of lymph node involvement","volume":"194","author":"Akiyama","year":"1981","journal-title":"Ann Surg"},{"key":"2021070907202908000_bib2","first-page":"49","article-title":"Recurrence of intrathoracic esophageal cancer","volume":"15","author":"Isono","year":"1985","journal-title":"Jpn J Clin Oncol"},{"key":"2021070907202908000_bib3","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1046\/j.1365-2168.2000.01527.x","article-title":"Estimation of lymph node metastasis by size in patients with intrathoracic oesophageal cancer","volume":"87","author":"Funai","year":"2000","journal-title":"Br J Surg"},{"key":"2021070907202908000_bib4","volume-title":"Guidelines for the Clinical and Pathologic Studies on Carcinoma of the Oesophagus","author":"Japanese Society for Oesophageal Disease","year":"1999","edition":"9th"},{"key":"2021070907202908000_bib5","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/00000658-199511000-00008","article-title":"Mortality and morbidity rates, postoperative course, quality of life, and prognosis after extended radical lymphadenectomy for esophageal cancer. 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