{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T08:05:25Z","timestamp":1697443525822},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Intestinal metaplasia persists in Barrett's mucosa despite control of reflux. Tissue homeostasis is maintained by the balance between apoptosis and proliferation. There is an unexplained temporary increase in proliferation in patients with Barrett's mucosa after antireflux surgery, and the long-term effect of any therapy in altering this balance remains unclear. The aim of this study was to assess apoptosis in Barrett's oesophagus following antireflux surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Apoptosis was evaluated in endoscopic biopsy specimens from 19 patients with Barrett's oesophagus 4 years after Collis\u2013Nissen gastroplasty using an in situ terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate\u2013biotin nick end labelling (TUNEL) method.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Intestinal metaplasia had a lower apoptosis index than gastric metaplasia (0\u00b727 versus 2\u00b714 per cent; P &amp;lt; 0\u00b7001). After operation there was a steady increase of apoptosis in intestinal metaplasia over time (from 0\u00b723 per cent before operation to 0\u00b742 per cent within 2 years and to 0\u00b759 per cent 4 years after operation; P = 0\u00b7015). Patients with persistent acid exposure did not show any increase in apoptosis in comparison with patients without acid exposure (0\u00b741 versus 0\u00b759 per cent; P = 0\u00b791).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Apoptosis is less in intestinal metaplasia than in gastric metaplasia, although there is an increase after antireflux surgery. Persistent acid reflux may predispose to malignancy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1046\/j.1365-2168.2002.02229.x","type":"journal-article","created":{"date-parts":[[2002,10,29]],"date-time":"2002-10-29T11:07:21Z","timestamp":1035889641000},"page":"1444-1449","source":"Crossref","is-referenced-by-count":10,"title":["Apoptosis in Barrett's oesophagus following antireflux surgery"],"prefix":"10.1093","volume":"89","author":[{"given":"L Q","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Surgery, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C Y","family":"Hu","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Institut de Recherches Cliniques de Montr\u00e9al, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Der Sarkissian","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Universit\u00e9 de Montr\u00e9al, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Ferraro","sequence":"additional","affiliation":[{"name":"Department of Surgery, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Pera","sequence":"additional","affiliation":[{"name":"Section of Gastrointestinal Surgery, Institute of Digestive Diseases, University of Barcelona Medical School, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"deBlois","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Universit\u00e9 de Montr\u00e9al, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Gaboury","sequence":"additional","affiliation":[{"name":"Department of Pathology, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A C","family":"Duranceau","sequence":"additional","affiliation":[{"name":"Department of Surgery, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,12,2]]},"reference":[{"key":"2021070906021734000_bib1","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/S0016-5085(97)70025-8","article-title":"Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota","volume":"112","author":"Locke","year":"1997","journal-title":"Gastroenterology"},{"key":"2021070906021734000_bib2","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1053\/gast.1996.v110.agast960614","article-title":"The columnar-lined esophagus, intestinal metaplasia, and Norman Barrett","volume":"110","author":"Spechler","year":"1996","journal-title":"Gastroenterology"},{"key":"2021070906021734000_bib3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0002-9610(85)80031-3","article-title":"Barrett's esophagus: its prevalence and association with adenocarcinoma in patients with symptoms of gastroesophageal reflux","volume":"149","author":"Sarr","year":"1985","journal-title":"Am J Surg"},{"key":"2021070906021734000_bib4","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1055\/s-2007-1010425","article-title":"Barrett's esophagus: results of a multicentric survey. 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