{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T04:39:27Z","timestamp":1761021567655},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T00:00:00Z","timestamp":1223510400000},"content-version":"vor","delay-in-days":2869,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:p>Achondroplasia in mice is a recessive genetic disorder, characterized by disproportionate dwarfism with reduced bone growth. The cause of this chondrodystrophy is unknown.<\/jats:p><jats:p>In this study normal and achondroplastic mouse chondrocytes were cultured in monolayer primary culture, their differentiation was verified by immunofluorescence and their growth was compared.<\/jats:p><jats:p>The results showed that achondroplastic cells exhibited a higher proliferative activity than control cells of the same age, confirmed also by a thymidine incorporation assay. Furthermore, basic fibroblast growth factor treatment was found to induce a strong increase in growth of normal mouse chondrocytes, while it did not stimulate statistically significant proliferation of achondroplastic mouse cells.<\/jats:p><jats:p>We suppose that this different growth rate could play a role in achondroplastic phenotype development.<\/jats:p>","DOI":"10.1046\/j.1365-2184.2000.00185.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T13:38:47Z","timestamp":1047389927000},"page":"397-405","source":"Crossref","is-referenced-by-count":3,"title":["In vitro proliferation of achondroplastic and normal mouse chondrocytes, before and after basic fibroblast growth factor stimulation"],"prefix":"10.1111","volume":"33","author":[{"given":"G.","family":"Argentin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Cicchetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02634541"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(98)90067-1"},{"key":"e_1_2_6_4_1","first-page":"241","article-title":"Histological and histochemical investigations of achondroplastic mice: a possible model of human achondroplasia","volume":"40","author":"Bonucci E","year":"1976","journal-title":"Growth"},{"key":"e_1_2_6_5_1","first-page":"299","article-title":"An electron microscope investigation of cartilage and bone in achondroplastic (cn\/cn) mice","volume":"9","author":"Bonucci E","year":"1977","journal-title":"J. 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