{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:34:56Z","timestamp":1761057296883},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":1364,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[1998,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Acute eosinophilic pneumonia (AEP) is characterized by respiratory distress, eosinophilic infiltration in the lung, acute onset, resolution of symptoms with corticosteroids and the absence of relapse. Studies to identify the pathophysiology of AEP in adults have demonstrated eosinophil activation in the BAL fluid, and the presence of high levels of interleukin 5 (IL\u20105) in the BAL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the pathophysiology of AEP with pleural effusion in a paediatric patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>ECP levels in the BALand pleural fluid was determined by radioimmunoassay. IL\u20105 and GM\u2010CSF concentrations in the BAL and pleural fluid were measured by Elisa. Immunohistochemistry studies performed on open lung biopsy included a specific ICAM\u20101 immunostaining and a ECP specific immunostaining (EG2<jats:sup>+<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High levels of ECP were found in the BAL (5\u2003\u03bcg\/L) and pleural fluid (750\u2003\u03bcg\/L) demonstrating eosinophil activation at these sites. Immunohistochemistry illustrated activated (EG2<jats:sup>+<\/jats:sup>) eosinophils in the interalveolar septa and alveolar space and detected increased expression of ICAM\u20101 on alveolar epithelial cells. High levels of IL\u20105 were measured in the BAL (1334\u2003pg\/mL) and pleural fluid (7014\u2003pg\/mL), while elevated concentrations of GM\u2010CSF (150\u2003pg\/mL) were found in the BAL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that in this paediatric patient with AEP activated eosinophils were present in the BAL fluid, in the interalveolar septa and in the pleural space while increased ICAM\u20101 expression was detected on alveolar epithelial cells, contributing, at least partly, for their adhesive interactions. IL\u20105 and GM\u2010CSF are likely important to the massive eosinophil recruitment and activation in the lung, while IL\u20105 is probably related to eosinophil accumulation and activation in the pleural space. Thus, lung generation of eosinophil\u2010active cytokines is central to the pathophysiology of AEP in paediatric patients.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1365-2222.1998.00231.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T09:31:54Z","timestamp":1047375114000},"page":"504-509","source":"Crossref","is-referenced-by-count":12,"title":["Mechanisms of acute eosinophilic inflammation in a case of acute eosinophilic pneumonia in a 14\u2010year\u2010old girl"],"prefix":"10.1111","volume":"28","author":[{"family":"Godding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Bodart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Delos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Sibille","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Galanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"DE Coster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Jarjour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Busse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198908313210903"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.5.7952571"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.5.1462"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/145.3.716"},{"key":"e_1_2_4_6_2","first-page":"358","article-title":"Acute eosinophilic pneumonia following intentional inhalation of Scotchguard","volume":"71","author":"Kelly KJ","year":"1993","journal-title":"Ann Allergy"},{"key":"e_1_2_4_7_2","first-page":"1259","article-title":"Adhesion molecules on eosinophils in acute eosinophilic pneumonia","volume":"151","author":"Okubo Y","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.34.65"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70206-3"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.104.2.493"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05227.x"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70110-9"},{"key":"e_1_2_4_13_2","first-page":"593","article-title":"Pneumopathie eosinophilique aig\u00fce et syndrome de larva migrans","volume":"11","author":"Bouchard O","year":"1994","journal-title":"Rev Mal Resp"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90412-0"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01003167"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.6_Pt_2.S31"},{"key":"e_1_2_4_17_2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1242\/jcs.107.2.443","article-title":"Constitutive expression of MHC and adhesion molecules by alveolar epithelial cells (type II pneumocytes) isolated from human lung and comparison with immunocytochemical findings","volume":"107","author":"Cunningham AC","year":"1994","journal-title":"J Cell Sci"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.103.2.475"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.4.7921434"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.102.4.1296"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.4.8616578"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/8.6.633"},{"key":"e_1_2_4_23_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.13.5.7576691"},{"key":"e_1_2_4_24_2","doi-asserted-by":"crossref","first-page":"4774","DOI":"10.4049\/jimmunol.156.12.4774","article-title":"Respiratory syncytial virus infection enhances neutrophil and eosinophil adhesion to cultured respiratory epithelial cells","volume":"156","author":"Stark JM","year":"1996","journal-title":"J Immunol"}],"container-title":["Clinical &amp; 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