{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T05:10:43Z","timestamp":1698642643741},"reference-count":0,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":510,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>A recent investigation has suggested that citrus red mite (<jats:italic>Panonychus citri<\/jats:italic>, CRM) is a common sensitizing allergen among children living around citrus farms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>A cross\u2010sectional survey was performed to evaluate the bronchial responsiveness to methacholine in CRM\u2010sensitive children without asthmatic symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and methods<\/jats:title><jats:p>A total of 375 children living around citrus farms were enrolled in this study. There were 201 boys and 174 girls with a mean age of 12.5 (range 7\u201316) years. Each subject was evaluated by a questionnaire, a skin prick test with 13 common inhalant allergens including CRM, and a methacholine bronchial provocation test (MBPT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Positive rate of MBPT (PC<jats:sub>20<\/jats:sub>\u2010methacholine &lt;\u200325\u2003mg\/mL) was higher in atopic rhinitic and atopic control children than in nonatopic rhinitic and nonatopic control subjects (41.3% and 33.3% vs 17.2% and 15.4%, respectively, both <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Slope of dose\u2013response curve (DRS, %\/mg\/mL) was higher in atopic rhinitic children than in nonatopic rhinitic, atopic control and nonatopic control subjects (14.3\u2003\u00b1\u20030.87 vs 9.4\u2003\u00b1\u20030.72, 10.0\u2003\u00b1\u20031.37 and 9.2\u2003\u00b1\u20031.51, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05, respectively). Both the positive rate of MBPT and the DRS were increased in children with positive skin response to CRM than in those without sensitization (48.2% vs 22.9%, <jats:italic>P<\/jats:italic>\u2003=\u20030.0001; 15.6\u2003\u00b1\u20031.26 vs 10.2\u2003\u00b1\u20030.65, <jats:italic>P<\/jats:italic>\u2003=\u20030.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bronchial responsiveness is increased in citrus red mite\u2010sensitive children even if they have no asthmatic symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1365-2222.2000.00862.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T09:44:07Z","timestamp":1047375847000},"page":"1129-1134","source":"Crossref","is-referenced-by-count":9,"title":["Bronchial responsiveness to methacholine is increased in citrus red mite (<i>Panonychus citri<\/i>)\u2010sensitive children without asthmatic symptoms"],"prefix":"10.1111","volume":"30","author":[{"family":"Min","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Son","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2222.2000.00862.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2222.2000.00862.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2222.2000.00862.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T13:59:31Z","timestamp":1698587971000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2222.2000.00862.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["10.1046\/j.1365-2222.2000.00862.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2222.2000.00862.x","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8]]}}}