{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T17:36:39Z","timestamp":1793208999997,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,7,7]],"date-time":"2008-07-07T00:00:00Z","timestamp":1215388800000},"content-version":"vor","delay-in-days":2775,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:p>Oral <jats:italic>Lactobacillus rhamnosus<\/jats:italic> GG ingestion for 5\u2003days to 4\u2003weeks has been shown to alleviate clinical symptoms of gastrointestinal inflammation and atopic dermatitis.<\/jats:p><jats:p>To determine whether oral <jats:italic>Lactobacillus rhamnosus<\/jats:italic> GG may act by generating immunosuppressive mediator in atopic children.<\/jats:p><jats:p> <jats:italic>Lactobacillus rhamnosus<\/jats:italic> GG (ATCC 53103) at a daily dose of 2\u2003\u00d7\u200310<jats:sup>10<\/jats:sup> cfu was added for 4\u2003weeks to the diets of nine children (mean age, 21\u2003months) with atopic dermatitis. Blood and faecal samples were collected before supplementation and at early (2\u2003weeks) and late stage (4 and 8\u2003weeks from the beginning). The concentrations of interleukin\u20106 (IL\u20106), IL\u201010, IL\u201012, tumour necrosis factor\u2010\u03b1 (TNF\u03b1) and interferon\u2010\u03b3 (IFN\u03b3) in sera, as well as the production of IL\u20102, IL\u20104, IL\u201010 and IFN\u03b3 in mitogen\u2010induced peripheral blood mononuclear cells, were assessed. Secretory IgA and TNF\u03b1 were also determined in faeces.<\/jats:p><jats:p>The serum IL\u201010 concentration differed significantly between before, early and\u00a0late samples (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) due to the elevation of serum IL\u201010 in the later phase of oral\u00a0<jats:italic>Lactobacillus rhamnosus<\/jats:italic> GG ingestion. The enhancement of IL\u201010 production in mitogen\u2010induced cultures preceded the rise in serum IL\u201010.<\/jats:p><jats:p>The enhanced IL\u201010 generation <jats:italic>in vivo<\/jats:italic> substantiates the anti\u2010inflammatory properties of specific probiotic bacteria strains, and provides an additional reason for considering such treatments for patients with intestinal inflammation.<\/jats:p>","DOI":"10.1046\/j.1365-2222.2000.00948.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T09:41:50Z","timestamp":1047375710000},"page":"1804-1808","source":"Crossref","is-referenced-by-count":333,"title":["Interleukin\u201010 generation in atopic children following oral <i>Lactobacillus rhamnosus<\/i> GG"],"prefix":"10.1111","volume":"30","author":[{"given":"T.","family":"Pessi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"S\u00fctas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hurme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Isolauri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19980108"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.72.1.51"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70093-9"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-997-0001-1"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.64.12.5403-5405.1996"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00711.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.150.2.353"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1985.tb00253.x"},{"key":"e_1_2_6_10_2","first-page":"1956","article-title":"Overexpression of IL\u201010 in atopic dermatitis","volume":"154","author":"Ohmen JD","year":"1995","journal-title":"J Immunol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.6.9804011"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1996.tb00110.x"},{"key":"e_1_2_6_13_2","first-page":"116","article-title":"Epidemiology of atopic dermatitis","volume":"21","author":"Hanifin JM","year":"1987","journal-title":"Monogr Allergy"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70277-4"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365518209168133"},{"key":"e_1_2_6_16_2","first-page":"61","article-title":"Mechanisms of food allergy","volume":"8","author":"Sampson HA","year":"1996","journal-title":"Annu Rev Nutr"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1996.tb00078.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70505-1"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1998.00449.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.12.2313"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(98)75549-3"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70197-5"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70177-6"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9247454"}],"container-title":["Clinical &amp; 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