{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:07:11Z","timestamp":1772222831410,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,7,7]],"date-time":"2008-07-07T00:00:00Z","timestamp":1215388800000},"content-version":"vor","delay-in-days":2713,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:p>In a subset of patients with asthma, aspirin and several other non\u2010steroidal anti\u2010inflammatory drugs (NSAID) that inhibit simultaneously cyclooxygenase\u20101 (COX\u20101) and cyclooxygenase\u20102 (COX\u20102) precipitate dangerous asthmatic attacks.<\/jats:p><jats:p>We tested the hypothesis that in patients with aspirin\u2010induced asthma the attacks are triggered by inhibition of COX\u20101 and not COX\u20102.<\/jats:p><jats:p>In twelve asthmatic patients (seven men, five women, average age 39\u2003years) oral aspirin challenge precipitated symptoms of bronchial obstruction with fall in FEV<jats:sub>1<\/jats:sub>\u2003&gt;\u200320%, and a rise in urinary leukotriene E<jats:sub>4<\/jats:sub> (LTE<jats:sub>4<\/jats:sub>) excretion; also in five patients the stable metabolite of PGD<jats:sub>2<\/jats:sub>, 9\u03b111\u03b2PGF<jats:sub>2<\/jats:sub>, increased in urine. The patients then entered a double\u2010blind, placebo\u2010controlled, cross\u2010over study in which they received either placebo or rofecoxib in increasing doses 1.5\u201325.0\u2003mg for 5 consecutive days, separated by a 1\u2010week wash\u2010out period. No patient on rofecoxib developed dyspnoea or fall in FEV<jats:sub>1<\/jats:sub>\u2003&gt;\u200320%; mean urinary LTE<jats:sub>4<\/jats:sub> and 9\u03b111\u03b2PGF<jats:sub>2<\/jats:sub> urinary levels, measured on each study day for 6\u2003h post\u2010dosing, remained unchanged. Two patients on placebo experienced moderate dyspnoea without alterations in urinary metabolites excretion. At least 2 weeks after completion of the study, all patients received on an open basis 25\u2003mg rofecoxib without any adverse effects.<\/jats:p><jats:p>NSAID that inhibit COX\u20101, but not COX\u20102, trigger asthmatic attacks in patients with asthma and aspirin intolerance. 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