{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T06:32:06Z","timestamp":1697610726721},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2002,1,12]],"date-time":"2002-01-12T00:00:00Z","timestamp":1010793600000},"content-version":"vor","delay-in-days":164,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:p><jats:bold>Background<\/jats:bold> Several studies have shown that interleukin (IL)\u20104 and interferon\u2010gamma (IFN\u2010\u03b3) are important for the regulation of immunoglobulin E (IgE) production and that IL\u201018 and IL\u201012 induce IFN\u2010\u03b3.<\/jats:p><jats:p><jats:bold>Objective<\/jats:bold> IFN\u2010\u03b3 production in response to IL\u201018 or IL\u201012 stimulation was investigated in peripheral blood mononuclear cells (PBMCs) of atopic patients with various levels of serum IgE.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> Cytokine production from PBMCs was measured following stimulation with a non\u2010specific stimulator (phytohemagglutinin: PHA), IL\u201018 or IL\u201012 in 12 healthy controls and 26 atopic patients with various serum IgE levels.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> IFN\u2010\u03b3 production by IL\u201018\u2010stimulated PBMCs was positively correlated with IFN\u2010\u03b3 production by IL\u201012\u2010stimulated PBMCs (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). However some atopic patients showed discrepancy between the levels of IFN\u2010\u03b3 production stimulated by IL\u201012 and by IL\u201018.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> The results shown here suggest the presence of abnormalities in the IL\u201012 and\/or IL\u201018 signalling pathways, such as genetic defects in the atopic patients.<\/jats:p>","DOI":"10.1046\/j.1365-2222.2001.01141.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T09:48:39Z","timestamp":1047376119000},"page":"1263-1270","source":"Crossref","is-referenced-by-count":19,"title":["IFN\u2010\u03b3 production in response to IL\u201018 or IL\u201012 stimulation by peripheral blood mononuclear cells of atopic patients"],"prefix":"10.1111","volume":"31","author":[{"given":"H.","family":"Shikano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kasahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Takemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,1,12]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(80)90026-3"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12371746"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(05)80010-7"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1993.tb05957.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(91)90213-8"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1995.tb01088.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.2.463"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.4049\/jimmunol.140.12.4193","article-title":"IL\u20104 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants","volume":"140","author":"Del Prete G","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"949","DOI":"10.4049\/jimmunol.136.3.949","article-title":"T cell activity that enhances poly\u2010clonal IgE production and its inhibition by interferon\u2010gamma","volume":"136","author":"Coffman RL","year":"1986","journal-title":"J Immunol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3107127"},{"key":"e_1_2_5_12_2","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.4049\/jimmunol.140.4.1022","article-title":"Interferon\u2010\u03b3 regulates the isotypes of Ig secreted during in vivo humoral immune responses","volume":"140","author":"Finkelman FD","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.4049\/jimmunol.141.4.1218","article-title":"IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL\u20104 and suppressed by IFN\u2010gamma","volume":"141","author":"Pene J","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.4049\/jimmunol.146.6.1836","article-title":"CD40 stimulation provides an IFN\u2010\u03b3\u2010independent and IL\u20104\u2010dependent differentiation signal directly to human B cells for IgE production","volume":"146","author":"Zhang KE","year":"1991","journal-title":"J Immunol"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1998.00188.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114368"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/378088a0"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.4.869"},{"key":"e_1_2_5_19_2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4049\/jimmunol.148.1.92","article-title":"Mechanisms of IFN\u2010\u03b3 induction by natural killer cell stimulatory factor (NKSF\/IL\u201012). Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL\u20102","volume":"148","author":"Chan SH","year":"1992","journal-title":"J Immunol"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80378-7"},{"key":"e_1_2_5_21_2","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.4049\/jimmunol.161.7.3400","article-title":"IL\u201012 up\u2010regulates IL\u201018 receptor expression on T cells, Th1 cells, and B cells: synergism with IL\u201018 for IFN\u2010\u03b3 production","volume":"161","author":"Yoshimoto T","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00931.x"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1859"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(84)80008-1"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00482.x"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.5.2701"},{"key":"e_1_2_5_27_2","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.4049\/jimmunol.160.8.3642","article-title":"IL\u201012 and IL\u201018 differentially regulate the transcriptional activity of the human IFN\u2010\u03b3 promoter in primary CD4+ T lymphocytes","volume":"160","author":"Barbulescu K","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70518-X"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.1998.18.1077"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2222.2001.01141.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2222.2001.01141.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2222.2001.01141.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T20:37:43Z","timestamp":1697575063000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2222.2001.01141.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["10.1046\/j.1365-2222.2001.01141.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2222.2001.01141.x","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8]]}}}