{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:31:01Z","timestamp":1791174661915,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2002,11,6]],"date-time":"2002-11-06T00:00:00Z","timestamp":1036540800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> The increase of atopic disorders in developed countries has been associated with the decline of infectious diseases, including helminthic infections. We have already demonstrated that adult worm extracts from <jats:italic>Ascaris suum<\/jats:italic> (ASC) suppress the IgE antibody production against unrelated antigens.<\/jats:p><jats:p><jats:bold>Objective<\/jats:bold> Here we investigated the influence of ASC on the development of pulmonary eosinophilic inflammation in a murine model of asthma.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> Heat\u2010coagulated egg white alone (EWI) or mixed with ASC (EWI\u2003+\u2003ASC) was implanted subcutaneously in B10.A or C57BL\/6 mice, and 14\u2003days later they were challenged intratracheally with OVA or exposed to aerosolized OVA for 4\u2003days.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> The suppressive effect of ASC was demonstrated on the accumulation of cells into airways, with reduction of eosinophil numbers and of eosinophil peroxidase activity in EWI\u2003+\u2003ASC\u2010 immunized mice. This effect correlated with a marked reduction of IL\u20105 and IL\u20104 levels in the BAL from C57BL\/6 and B10.A mice, respectively, and of eotaxin in BAL and lung tissue from both strains. OVA\u2010specific IgG1 and IgE levels were also impaired in serum and BAL from these mice. Airway hyper\u2010reactivity to methacholine was obtained in B10.A mice sensitized with EWI, but the respiratory mechanical parameters returned to normal levels in EWI\u2003+\u2003ASC\u2010immunized mice.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold> These results indicate that ASC has a profound inhibitory effect on lung inflammation and hyper\u2010responsiveness and that suppression of IL\u20105 or IL\u20104 and of eotaxin contributes to this effect.<\/jats:p>","DOI":"10.1046\/j.1365-2222.2002.01506.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T09:49:44Z","timestamp":1047376184000},"page":"1659-1666","source":"Crossref","is-referenced-by-count":70,"title":["Eosinophilic inflammation and airway hyper\u2010responsiveness are profoundly inhibited by a helminth (<i>Ascaris suum<\/i>) extract in a murine model of asthma"],"prefix":"10.1111","volume":"32","author":[{"given":"C.","family":"Lima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Perini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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