{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T16:01:03Z","timestamp":1785600063234,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> The Th2 immune response in the nasal mucosa of subjects with allergic rhinitis is mediated by allergen\u2010specific IgE. Moreover, these subjects show positive responses for markers of systemic atopy, including allergen\u2010specific skin sensitivity and raised serum IgE titres. In contrast, idiopathic rhinitis (IR) subjects with similar histological nasal mucosal features differ in being defined as non\u2010allergic because they have negative atopic responses.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> We hypothesized that it is possible to have an allergic Th2 disease pathway localized in the nasal mucosa of \u2018non\u2010allergic\u2019 rhinitis subjects despite an absence of atopic responses.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> The presence of house dust mite and grass pollen\u2010specific IgE antibodies was investigated in non\u2010atopic (<jats:italic>n<\/jats:italic>=10) and atopic (<jats:italic>n<\/jats:italic>=11) subjects with persistent rhinitis and compared to normal (<jats:italic>n<\/jats:italic>=12) control subjects. Biotin\u2010labelled allergen was used to localize specific allergen\u2010binding antibodies <jats:italic>in situ<\/jats:italic> in sections of nasal mucosa.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Grass pollen allergen binding was detected in the nasal mucosa of 3\/10 non\u2010atopic IR subjects but, in contrast, dust mite\u2010specific antibodies were not detected. Specific antibodies were present in a total of 8\/11 mucosal samples from the allergic group, but none was detected in normal control tissues.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> These findings support the concept of localized nasal allergy in \u2018non\u2010atopic\u2019 rhinitis subjects. We propose the term \u2018<jats:italic>entopy<\/jats:italic>\u2019 to define this phenomenon and believe that this concept has a wider implication for localized allergic responses in other mucosal sites.<\/jats:p>","DOI":"10.1046\/j.1365-2222.2003.01737.x","type":"journal-article","created":{"date-parts":[[2003,10,14]],"date-time":"2003-10-14T10:55:05Z","timestamp":1066128905000},"page":"1374-1379","source":"Crossref","is-referenced-by-count":172,"title":["\u2018<i>Entopy<\/i>\u2019: localized mucosal allergic disease in the absence of systemic responses for atopy"],"prefix":"10.1111","volume":"33","author":[{"given":"D. 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