{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:56:47Z","timestamp":1790312207001,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2003,9,22]],"date-time":"2003-09-22T00:00:00Z","timestamp":1064188800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> The relationships between immunological reactivity and bronchial responsiveness to allergen and non\u2010specific bronchial responsiveness are unclear in occupational asthma caused by low molecular weight substances.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> We assessed the above relationships in green tea\u2010induced asthma, an occupational asthma of green tea factory workers, in which epigallocatechin gallate (EGCg), a low molecular weight component of green tea leaves, is the causative agent.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Subjects consisted of 21 patients suspected of having green tea\u2010induced asthma, on whom skin test and inhalation challenge with EGCg were performed. The skin sensitivity or end\u2010point titration to EGCg as a measure of immunological reactivity, together with the provocative concentrations causing a 20% or greater fall in forced expiratory volume in 1\u2003s (PC<jats:sub>20<\/jats:sub>) of EGCg and methacholine, were determined.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> We found that 11 patients had green tea\u2010induced asthma, with immediate asthmatic reactions in eight and dual asthmatic reactions in three. We also found that 11 of 13 patients (85%) with immunological reactivity and bronchial hyper\u2010responsiveness to methacholine experienced an asthmatic reaction and that no subject without immunological reactivity reacted. There were significant correlations among skin sensitivity, EGCg PC<jats:sub>20<\/jats:sub> and methacholine PC<jats:sub>20<\/jats:sub>. Multiple linear regression analysis showed the relationship: log (EGCg PC<jats:sub>20<\/jats:sub>)=0.42\u2003log (skin sensitivity)+1.17\u2003log (methacholine PC<jats:sub>20<\/jats:sub>)+0.93 (<jats:italic>r<\/jats:italic>=0.796, <jats:italic>P<\/jats:italic>&lt;0.05).<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> It is concluded that bronchial responsiveness to EGCg can be highly satisfactorily predicted by skin sensitivity to EGCg and bronchial responsiveness to methacholine.<\/jats:p>","DOI":"10.1046\/j.1365-2222.2003.01744.x","type":"journal-article","created":{"date-parts":[[2004,4,6]],"date-time":"2004-04-06T14:12:48Z","timestamp":1081260768000},"page":"1252-1255","source":"Crossref","is-referenced-by-count":32,"title":["Green tea\u2010induced asthma: relationship between immunological reactivity, specific and non\u2010specific bronchial responsiveness"],"prefix":"10.1111","volume":"33","author":[{"given":"T.","family":"Shirai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Reshad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Yoshitomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Chida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,9,22]]},"reference":[{"issue":"13","key":"e_1_2_6_2_2","first-page":"187","article-title":"Hypersensibilit\u00e9 cholinergo\u2010histaminique pulmonaire de l'asthmatique","author":"Tiffeneau R.","year":"1958","journal-title":"relation avec l'hypersensibilit\u00e9 allerg\u00e9nique pulmonaire"},{"key":"e_1_2_6_3_2","first-page":"523","article-title":"Bronchial histamine reactivity","volume":"6","author":"Bryant DH","year":"1976","journal-title":"its relationship to the reactivity of the bronchi to allergens"},{"key":"e_1_2_6_4_2","first-page":"1053","article-title":"Determinants of allergen\u2010induced asthma","volume":"120","author":"Cockcroft DW","year":"1979","journal-title":"dose of allergen, circulating IgE antibody concentration, and bronchial responsiveness to inhaled histamine"},{"key":"e_1_2_6_5_2","first-page":"264","article-title":"Prediction of airway responsiveness to allergen from skin sensitivity to allergen and airway responsiveness to histamine","volume":"135","author":"Cockcroft DW","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09020211"},{"key":"e_1_2_6_7_2","first-page":"1801","article-title":"Epigallocatechin gallate","volume":"106","author":"Shirai T","year":"1994","journal-title":"the major causative agent of green tea-induced asthma"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63087-6"},{"key":"e_1_2_6_9_2","first-page":"167","article-title":"Skin tests used in type I allergy testings Position paper of the European Academy of Allergy and Clinical Immunology","volume":"33","author":"Dreborg S","year":"1989","journal-title":"Allergy"},{"key":"e_1_2_6_10_2","first-page":"167","article-title":"Clinical evaluation of standard method of acetylcholine inhalation test in bronchial asthma","volume":"33","author":"Makino S","year":"1984","journal-title":"Jpn J Allergol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.3.9910031"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2222.2003.01744.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2222.2003.01744.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2222.2003.01744.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T17:53:55Z","timestamp":1697219635000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2222.2003.01744.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["10.1046\/j.1365-2222.2003.01744.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2222.2003.01744.x","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9]]}}}