{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:55:36Z","timestamp":1791028536746,"version":"4.1.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1998,6,1]],"date-time":"1998-06-01T00:00:00Z","timestamp":896659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,12,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Type IX collagen (CIX), a cartilage-specific glycoprotein, constitutes \u2264\u200310% of cartilage collagen. To ascertain whether CIX can induce arthritis as shown for type II and XI collagen (CII and CXI), outbred rats were sensitized with bovine, chick and human CIX; inbred rats, mice, and guinea pigs were sensitized with bovine CIX. Mice and guinea pigs proved resistant to arthritis, as did rats sensitized with CIX\/Freund's incomplete adjuvant (FIA). Arthritis was seen in rats when 100\u2003\u03bcg of Mycobacterium tuberculosis (Mtb) were added to FIA, but seldom with smaller doses of Mtb, suggesting the arthritis was adjuvant-induced. High levels of antibodies to rat CIX, containing complement-fixing subclasses, were detected in rat sera in addition to DTH and lymphocyte proliferation responses to rat CIX. Given the potential for CIX-induced disease, CIX-sensitized rats were injected intraperitoneally with lipopolysaccharide (LPS) to stimulate proinflammatory cytokine release, and intra-articularly with rat CIX to stimulate arthritis. LPS stimulation was ineffective; however, intra-articularly injected CIX produced transient synovitis. When rats with stable adjuvant arthritis were sensitized with CIX\/FIA, significant increases in paw volume were measured compared with controls given CI\/FIA. Immunohistochemical studies of actively and passively sensitized rats revealed deposits of CIX antibody, but not C3, at the joint margins where proteoglycan staining was weak. Together, these findings suggest that autoimmunity to CIX, in contrast to CII and CXI, is not directly pathogenic but may contribute to joint injury provided arthritis is initiated by an independent disease process.<\/jats:p>","DOI":"10.1046\/j.1365-2249.1998.00577.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:11:12Z","timestamp":1047377472000},"page":"375-382","source":"Crossref","is-referenced-by-count":8,"title":["Immunity to type IX collagen in rodents: a study of type IX collagen for autoimmune and arthritogenic activities"],"prefix":"10.1093","volume":"112","author":[{"given":"M A","family":"Cremer","sequence":"first","affiliation":[{"name":"Research Service of the Veterans Affairs Medical Center and the Department of Medicine, University of Tennessee, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X J","family":"YE","sequence":"additional","affiliation":[{"name":"Research Service of the Veterans Affairs Medical Center and the Department of Medicine, University of Tennessee, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Terato","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center and the Department of Medicine, University of Utah, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M M","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center and the Department of Medicine, University of Utah, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W C","family":"Watson","sequence":"additional","affiliation":[{"name":"Research Service of the Veterans Affairs Medical Center and the Department of Medicine, University of Tennessee, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A H","family":"Kang","sequence":"additional","affiliation":[{"name":"Research Service of the Veterans Affairs Medical Center and the Department of Medicine, University of Tennessee, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"b1_85","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.108.1.191"},{"key":"b2_86","unstructured":"2 M Cremer, K Terato, and J Seyer Immunity to type XI collagen in mice. Evidence that alpha3 (XI) chain of type XI collagen and the alpha1 (II) chain of type II collagen share arthritogenic determinants and induce arthritis in DBA\/1 mice. 1991 ; 146 :4130, 7 ."},{"key":"b3_87","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.106.3.991"},{"key":"b4_88","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/ng0196-103","volume":"12","author":"Muragaki Y","year":"1996","journal-title":"Nat Genet"},{"key":"b5_89","doi-asserted-by":"crossref","first-page":"824","DOI":"10.4049\/jimmunol.153.2.824","volume":"155","author":"Cremer MA","year":"1994","journal-title":"J Immunol"},{"key":"b6_90","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3109\/08916939508993346","volume":"20","author":"Cremer MA","year":"1994","journal-title":"Autoimmunity"},{"key":"b7_91","unstructured":"7 MA Cremer . Collagen-induced arthritis. In: Greenwald RA, Diamond HS, eds. Handbook of animal models for the rheumatic diseases, Vol. 1. Boca Raton: CRC Press, 1988 : 17-27."},{"key":"b8_92","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1365-2249.1990.tb05444.x","volume":"82","author":"Cremer MA","year":"1990","journal-title":"Exp Immunol"},{"key":"b9_93","first-page":"265","volume":"39","author":"Ye XJ","year":"1990","journal-title":"J Histochem Cytochem"},{"key":"b10_94","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1994.1166"},{"key":"b11_95","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1155\/S0962935192000425","volume":"1","author":"Caccese RG","year":"1992","journal-title":"Med Inflammation"},{"key":"b12_96","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3109\/08916939508995311","volume":"22","author":"Terato K","year":"1995","journal-title":"Autoimmunity"},{"key":"b13_97","first-page":"619","volume":"63","author":"Hernandez AD","year":"1988","journal-title":"Immunol"},{"key":"b14_98","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1172\/JCI115164","volume":"87","author":"Jasin HE","year":"1991","journal-title":"J Clin Invest"},{"key":"b15_99","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1084\/jem.162.3.962","volume":"162","author":"Taurog JD","year":"1985","journal-title":"J Exp Med"},{"key":"b16_100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/art.1780330101","volume":"33","author":"Boissier M-C","year":"1990","journal-title":"Arthritis Rheum"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2249.1998.00577.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2249.1998.00577.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/112\/3\/375\/42206290\/j.1365-2249.1998.00577.x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/112\/3\/375\/42206290\/j.1365-2249.1998.00577.x.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T05:43:28Z","timestamp":1682055808000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/112\/3\/375\/6480529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,6]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2001,12,25]]},"published-print":{"date-parts":[[2001,12,25]]}},"URL":"https:\/\/doi.org\/10.1046\/j.1365-2249.1998.00577.x","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"value":"0009-9104","type":"print"},{"value":"1365-2249","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1998,6]]},"published":{"date-parts":[[1998,6]]}}}