{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:05:55Z","timestamp":1790514355288,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,12,24]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Complement component C6 is a part of the membrane attack complex that forms a pore-like structure in cell membranes following complement activation. Deficiency of terminal complement components including C6 predisposes individuals to infection with Neisseriae. Using polymerase chain reaction\/single-strand conformation polymorphism analysis followed by DNA sequencing, we screened genomic DNA from 200 randomly chosen blacks and an equal number from whites for three loss-of-function C6 mutations. Ten blacks and two whites were found to be heterozygous for one of the mutations. Two of the mutations, 1195delC and 1936delG, were found exclusively in black individuals. A third previously undescribed mutation, 878delA, was found at equal frequency among the two groups. The difference between the two groups was significant (P\u2003=\u20030.027), indicating that C6 deficiency due to these three mutations is more common among blacks than whites in the local area, principally Jefferson County, Alabama. In addition, three previously undescribed point mutations, two of which result in amino acid substitutions, were identified within exon 6. A review of the county health department records over the past 6 years revealed a higher incidence of meningococcal meningitis in blacks due to serogroups Y and W-135 which paralleled the difference in the estimated prevalence of C6 deficiency. Among black residents of the county (n\u2003=\u2003235\u2003598) there were 15 cases of meningitis due to these two serogroups, compared with two cases in the white population (n\u2003=\u2003422\u2003604) (P\u2003=\u20030.002). We conclude that C6 deficiency is more common among blacks than whites in the south-eastern United States, with a frequency approaching 1 in 1600 black individuals.<\/jats:p>","DOI":"10.1046\/j.1365-2249.2000.01113.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:20:50Z","timestamp":1047378050000},"page":"305-310","source":"Crossref","is-referenced-by-count":45,"title":["High prevalence of complement component C6 deficiency among African-Americans in the South-eastern USA"],"prefix":"10.1093","volume":"119","author":[{"given":"Z B","family":"Zhu","sequence":"first","affiliation":[{"name":"Division of Clinical Immunology and Rheumatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T P","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Division of Developmental and Clinical Immunology"},{"name":"Department of Paediatrics, School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K T","family":"Hovanky","sequence":"additional","affiliation":[{"name":"Division of Developmental and Clinical Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S B","family":"Boppana","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y L","family":"Dai","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology and Rheumatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Densen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, VA Medical Center and University of Iowa College of Medicine, Iowa City, IA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R C P","family":"Go","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J S","family":"Jablecki","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Jefferson County Department of Health, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J E","family":"Volanakis","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology and Rheumatology"},{"name":"Biomedical Sciences Research Centre \u2018A. 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