{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T15:17:05Z","timestamp":1769354225481,"version":"3.49.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,12,24]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The levels of soluble IL-2R\u03b1 (sIL-2R\u03b1) in serum were measured in HTLV-1 carriers and ATL patients in order to evaluate their possible correlation with clinical status. Mean sIL-2R levels in ATL patients were found to be 9704\u2003U\/ml for the acute\/lymphoma type, 1961\u2003U\/ml for the chronic type and 788\u2003U\/ml for the smouldering type. The level for asymptomatic HTLV-1 carriers was 475\u2003U\/ml, and 165\u2003U\/ml for healthy young adult HTLV-1\u2212 controls. The serial measurement of sIL-2R in ATL patients, healthy HTLV-1 carriers, and HTLV-1 carriers with diseases other than ATL showed a good correlation between serum levels of sIL-2R and the pathophysiological status of disease. Furthermore, an increase in the sIL-2R\u03b1 level in serum indicated the exacerbation of HTLV-1 infection and autoimmune diseases. The measurement of sIL-2R\u03b1 levels is therefore a very useful parameter for determining disease status.<\/jats:p>","DOI":"10.1046\/j.1365-2249.2000.01136.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:20:50Z","timestamp":1047378050000},"page":"259-263","source":"Crossref","is-referenced-by-count":19,"title":["Clinical significance of serum soluble IL-2R levels in patients with adult T cell leukaemia (ATL) and HTLV-1 carriers"],"prefix":"10.1093","volume":"119","author":[{"given":"K","family":"Araki","sequence":"first","affiliation":[{"name":"Department of Medical Technology, School of Health Science, Faculty of Medicine, University of the Ryukyu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, School of Health Science, Faculty of Medicine, University of the 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