{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T21:13:01Z","timestamp":1770498781394,"version":"3.49.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,12,24]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n               <jats:p>Autoantibodies against the transcriptional DEK protein have been considered characteristic of the pauciarticular onset subtype of juvenile rheumatoid arthritis (JRA) associated with iridocyclitis in young girls. In this study we investigated the presence of anti-DEK autoantibodies in the sera of 288 patients with SLE using a recombinant DEK protein as autoantigenic target. Thirty sera (10\u00b74%) were positive against DEK protein by immunoblotting. Patients with anti-DEK autoantibodies show a lower frequency of cutaneous manifestation, exhibit more frequently certain markers of a chronic inflammatory status like anaemia and positivity for C-reactive protein, as well as a higher frequency of anti-double-stranded DNA autoantibodies. In contrast to JRA patients positive for anti-DEK autoantibodies, no association with erosive arthritis nor iridocyclitis were found in SLE. In conclusion, our results show that 10\u00b74% of SLE patients from our area show antibodies against DEK protein, although this feature did not clearly establish a clinical subset of the disease.<\/jats:p>","DOI":"10.1046\/j.1365-2249.2000.01154.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:19:47Z","timestamp":1047377987000},"page":"530-532","source":"Crossref","is-referenced-by-count":21,"title":["Autoantibodies to DEK oncoprotein in systemic lupus erythematosus (SLE)"],"prefix":"10.1093","volume":"119","author":[{"given":"I","family":"Wichmann","sequence":"first","affiliation":[{"name":"Servicio de Inmunolog\u00eda, Hospital Universitario Virgen del Rocio, Servicio Andaluz de Salud, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Respaldiza","sequence":"additional","affiliation":[{"name":"Servicio de Inmunolog\u00eda, Hospital Universitario Virgen del Rocio, Servicio Andaluz de Salud, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J R","family":"Garcia-Lozano","sequence":"additional","affiliation":[{"name":"Servicio de Inmunolog\u00eda, Hospital Universitario Virgen del Rocio, Servicio Andaluz de Salud, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Montes","sequence":"additional","affiliation":[{"name":"Servicio de Inmunolog\u00eda, Hospital Universitario Virgen del Rocio, Servicio Andaluz de Salud, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Sanchez-Roman","sequence":"additional","affiliation":[{"name":"Servicio de Inmunolog\u00eda, Hospital Universitario Virgen del Rocio, Servicio Andaluz de Salud, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Nu\u00f1ez-Roldan","sequence":"additional","affiliation":[{"name":"Servicio de Inmunolog\u00eda, Hospital Universitario Virgen del Rocio, Servicio Andaluz de Salud, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"2022011221072509100_b1","first-page":"1687","article-title":"The translocation (6;9) associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek\u2013can mRNA","volume":"12","author":"Von Lindern","year":"1992","journal-title":"Mol Cell Biol"},{"key":"2022011221072509100_b2","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1073\/pnas.94.5.1811","article-title":"DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer","volume":"94","author":"Fu","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022011221072509100_b3","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1365-2249.1993.tb08214.x","article-title":"The putative oncoprotein DEK, part of a chimera protein associated with acute myeloid leukemia, is an autoantigen in juvenile rheumatoid arthritis","volume":"94","author":"Sierakowska","year":"1993","journal-title":"Clin Exp Immunol"},{"key":"2022011221072509100_b4","first-page":"2136","article-title":"A novel autoantibody to the putative oncoprotein DEK in pauciarticular onset juvenile rheumatoid arthritis","volume":"21","author":"Szer","year":"1994","journal-title":"J Rheumatol"},{"key":"2022011221072509100_b5","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1002\/1529-0131(199808)41:8<1505::AID-ART23>3.0.CO;2-N","article-title":"Autoantibodies to DEK oncoprotein in a patient with systemic lupus erythematosus and sarcoidosis","volume":"41","author":"Dong","year":"1998","journal-title":"Arthritis Rheum"},{"key":"2022011221072509100_b6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0198-8859(98)00085-8","article-title":"Autoantibodies to transcriptional regulation proteins DEK and ALY in a patient with systemic lupus erythematosus","volume":"60","author":"Wichmann","year":"1999","journal-title":"Human Immunol"},{"key":"2022011221072509100_b7","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/art.1780251101","article-title":"The 1982 revised criteria for the classification of systemic lupus erythematosus","volume":"25","author":"Tan","year":"1982","journal-title":"Arthritis Rheum"},{"key":"2022011221072509100_b8","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1972","journal-title":"Nature"},{"key":"2022011221072509100_b9","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","article-title":"Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications","volume":"76","author":"Towbin","year":"1979","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022011221072509100_b10","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/art.1780290401","article-title":"The lupus autoantigens and the pathogenesis of SLE","volume":"29","author":"Hardin","year":"1986","journal-title":"Arthritis Rheum"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2249.2000.01154.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2249.2000.01154.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/119\/3\/530\/42128861\/j.1365-2249.2000.01154.x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/119\/3\/530\/42128861\/j.1365-2249.2000.01154.x.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T11:47:07Z","timestamp":1676375227000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/119\/3\/530\/6461843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2001,12,24]]},"published-print":{"date-parts":[[2001,12,24]]}},"URL":"https:\/\/doi.org\/10.1046\/j.1365-2249.2000.01154.x","relation":{},"ISSN":["1365-2249","0009-9104"],"issn-type":[{"value":"1365-2249","type":"electronic"},{"value":"0009-9104","type":"print"}],"subject":[],"published-other":{"date-parts":[[2000,3]]},"published":{"date-parts":[[2000,3]]}}}