{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:58:03Z","timestamp":1790935083614,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,12,24]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Pathogenic mechanisms of the demyelinating encephalopathy featuring the nervous phase of human African trypanosomiasis (HAT) are largely unknown. They might include autoimmune disorders. A variety of autoantibodies is detected during the disease and we have previously evidenced anti-galactocerebroside (GalC) antibodies in the serum and cerebrospinal fluid (CSF) from patients in the nervous stage (stage II) of HAT. We now show that anti-GalC antibodies recognize an antigen located on the parasite membrane and common to different strains of trypanosomes. By using affinity chromatography with a rabbit anti-GalC antiserum, a 52-kD proteolipid was isolated from the membrane of Trypanosoma brucei (T.\u2003b.) brucei AnTat 1.9, AnTat 1.1E, and T.\u2003b. rhodesiense Etat 1.2\/R and Etat 1.2\/S. Antibodies directed against this antigen were found in the CSF from patients with nervous stage HAT. These CSF also contained anti-GalC antibodies and adsorption with the proteolipid decreased anti-GalC reactivity. Immunization of mice with this antigen induced the production of antibodies which cross-reacted with GalC but no protection from experimental infection with T.\u2003b. brucei. These data support the hypothesis that anti-GalC antibodies detected in the CSF from HAT patients might be induced by molecular mimicry with a parasite antigen.<\/jats:p>","DOI":"10.1046\/j.1365-2249.2000.01166.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:19:47Z","timestamp":1047377987000},"page":"516-522","source":"Crossref","is-referenced-by-count":6,"title":["Cross-reactivity of anti-galactocerebroside autoantibodies with a<i>Trypanosoma brucei<\/i>proteolipidic epitope"],"prefix":"10.1093","volume":"119","author":[{"given":"M","family":"Girard","sequence":"first","affiliation":[{"name":"Institute of Tropical Neurology, Faculty of Medicine, Limoges, Laboratories of Immunology"},{"name":"University Hospital, Limoges and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Bisser","sequence":"additional","affiliation":[{"name":"Institute of Tropical Neurology, Faculty of Medicine, Limoges, Laboratories of Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Buscher","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine, Department of Parasitology, Antwerpen, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Bouteille","sequence":"additional","affiliation":[{"name":"Institute of Tropical Neurology, Faculty of Medicine, Limoges, Laboratories of Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-L","family":"Preud\u2019Homme","sequence":"additional","affiliation":[{"name":"University Hospital, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M-O","family":"Jauberteau","sequence":"additional","affiliation":[{"name":"University Hospital, Limoges and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"2022011221072942900_b1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/0035-9203(80)90184-4","article-title":"The pathogenesis of sleeping sickness","volume":"74","author":"Greenwood","year":"1980","journal-title":"Trans Roy Soc Trop Med Hyg"},{"key":"2022011221072942900_b2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1365-2990.1986.tb00682.x","article-title":"Human African trypanosomiasis (T. b. gambiense). 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