{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T14:32:36Z","timestamp":1720276356153},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,12,24]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Although it has been shown that \u03b3\u03b4 T lymphocytes are able to react with different cell-associated or soluble antigens, the immune repertoire of these cells appears to be skewed to the recognition of mycobacterial antigens. We have studied the number and reactivity of \u03b3\u03b4 T cells towards several mycobacterial antigens in patients with tuberculosis and leprosy, as well as their healthy contacts and control individuals. We found an increased number of V\u03b42+ cells in healthy contacts (PPD+ and lepromin+) and tuberculoid leprosy patients. The \u03b3\u03b4 T cells from lepromatous leprosy showed a decreased response to all antigens tested, but some of these patients exhibited a significant response to the 30-kD glycoprotein of Mycobacterium tuberculosis. Interestingly, the reactivity of \u03b3\u03b4 T cells against mycobacterial antigens was significantly increased by costimulatory signals generated through CD7, LFA-1, CD50 and CD69 in all groups. However, signalling through CD69 did not enhance the responsiveness of \u03b3\u03b4 lymphocytes from lepromatous patients. On the other hand, the in\u2003vitro blockade of IL-10 with a specific antibody enhanced the cell proliferation of \u03b3\u03b4 lymphocytes from lepromatous leprosy patients, whereas exogenous IL-10 had an opposite effect in most individuals studied. These results suggest the potential role of different cell membrane receptors in the regulation of \u03b3\u03b4 T cell proliferation induced by mycobacteria, as well as the possible involvement of IL-10 in this phenomenon.<\/jats:p>","DOI":"10.1046\/j.1365-2249.2000.01226.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:22:02Z","timestamp":1047378122000},"page":"468-475","source":"Crossref","is-referenced-by-count":6,"title":["Co-stimulatory signals increase the reactivity of<i>\u03b3\u03b4<\/i>T cells towards mycobacterial antigens"],"prefix":"10.1093","volume":"120","author":[{"given":"R","family":"Gonz\u00e1lez-Amaro","sequence":"first","affiliation":[{"name":"Department of Immunology, Facultad de Medicina, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed, S.L.P"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D P","family":"Portales-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Immunology, Facultad de Medicina, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed, S.L.P"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Baranda","sequence":"additional","affiliation":[{"name":"Department of Immunology, Facultad de Medicina, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed, S.L.P"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Moncada","sequence":"additional","affiliation":[{"name":"Department of Immunology, Facultad de Medicina, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed, S.L.P"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Toro","sequence":"additional","affiliation":[{"name":"Department of Immunology, Facultad de Medicina, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed, S.L.P"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"L\u00f3pez-Briones","sequence":"additional","affiliation":[{"name":"Department of Immunology, Facultad de Medicina, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed, S.L.P"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Espitia","sequence":"additional","affiliation":[{"name":"Department of Immunology, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico, D.F., M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Mancilla","sequence":"additional","affiliation":[{"name":"Department of Immunology, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico, D.F., M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"2022011221073650600_b1","first-page":"3","article-title":"Global burden of tuberculosis","volume-title":"Tuberculosis pathogenesis, protection, and control","author":"Snider","year":"1994:"},{"key":"2022011221073650600_b2","doi-asserted-by":"crossref","first-page":"492","DOI":"10.4049\/jimmunol.158.1.492","article-title":"Patients with multidrug-resistant tuberculosis with low CD4+ T cell counts have impaired Th1 responses","volume":"158","author":"McDyer","year":"1997","journal-title":"J Immunol"},{"key":"2022011221073650600_b3","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.4049\/jimmunol.157.3.1271","article-title":"Effect of Mycobacterium tuberculosis on HIV replication. 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