{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T20:22:41Z","timestamp":1697660561938},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,10,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n               <jats:p>Haemophagocytic syndrome (HPS) and HIV infection are both associated with cytokine network dysregulation. We therefore analysed plasma levels and mRNA synthesis in peripheral blood mononuclear cells (PBMC) of cytokines, chemokines and chemokine receptors in one HIV-infected patient with HPS. We compared the results with those for eight HIV-infected patients with similar CD4+ T cell counts (207\/mm3versus controls: median 214\/mm3) and plasma virus load (4\u00b71 log copies\/ml, versus controls: median 4\u00b72 log copies\/ml). The HPS patient had a lower viral DNA load in PBMC and higher plasma levels of interferon-gamma, IL-10, and macrophage inflammatory protein (MIP)-1\u03b2. No difference in plasma tumour necrosis factor-alpha (TNF-\u03b1), IL-6 and MIP-1\u03b1 concentration was observed between the HPS patient and control patients. No difference was observed in TNF-\u03b1, IL-1\u03b2, IL-10, IL-4, MIP-1\u03b1, MIP-1\u03b2, RANTES, CXCR-4, and CCR-5 mRNA levels in PBMC, but IL-6 levels were higher in the HPS patient. Our results emphasize the role of IL-10 in the control of immune hyperactivation that is observed in HPS.<\/jats:p>","DOI":"10.1046\/j.1365-2249.2000.01288.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:22:44Z","timestamp":1047378164000},"page":"320-323","source":"Crossref","is-referenced-by-count":5,"title":["High levels of IL-10 and determination of other cytokines and chemokines in HIV-associated haemophagocytic syndrome"],"prefix":"10.1093","volume":"121","author":[{"given":"O","family":"Benveniste","sequence":"first","affiliation":[{"name":"CEA, Service de Neurovirologie, CRSSA, DRM\/DSV, Institut Paris-Sud sur les Cytokines, B.P. 6, Fontenay aux Roses Cedex"},{"name":"Service des Maladies Infectieuses et Tropicales, Groupe Hospitalier Bichat-Claude Bernard, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Dereuddre-Bosquet","sequence":"additional","affiliation":[{"name":"CEA, Service de Neurovirologie, CRSSA, DRM\/DSV, Institut Paris-Sud sur les Cytokines, B.P. 6, Fontenay aux Roses Cedex"},{"name":"SPI-BIO, Massy Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Clayette","sequence":"additional","affiliation":[{"name":"CEA, Service de Neurovirologie, CRSSA, DRM\/DSV, Institut Paris-Sud sur les Cytokines, B.P. 6, Fontenay aux Roses Cedex"},{"name":"SPI-BIO, Massy Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Leport","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales, Groupe Hospitalier Bichat-Claude Bernard, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-L","family":"Vild\u00e9","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales, Groupe Hospitalier Bichat-Claude Bernard, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Dormont","sequence":"additional","affiliation":[{"name":"CEA, Service de Neurovirologie, CRSSA, DRM\/DSV, Institut Paris-Sud sur les Cytokines, B.P. 6, Fontenay aux Roses Cedex"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,10,9]]},"reference":[{"key":"2022011221083027200_b1","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1182\/blood.V84.9.2840.2840","article-title":"Histiocytes and histiocytosis","volume":"84","author":"Cline","year":"1994","journal-title":"Blood"},{"key":"2022011221083027200_b2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0925-5710(97)00584-7","article-title":"Differential diagnosis of hemophagocytic syndrome: underlying disorders and selection of the most effective treatment","volume":"66","author":"Imashuku","year":"1997","journal-title":"Int J 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