{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:23:07Z","timestamp":1792088587332,"version":"4.4.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,12,24]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n               <jats:p>To clarify the role of Th1- and Th2-type cytokines in the various outcomes of human alveolar echinococcosis (AE), the cytokine immune response of self-cured patients was studied and compared with those of progressive AE patients and healthy subjects. Self-cured patients were divided into two groups according to the following clinical features: subjects who had positive Echinococcus multilocularis serologies and hepatic calcifications typical of AE were classified as \u2018abortive AE\u2019 patients, and those who had positive E. multilocularis serologies but no hepatic lesions or calcifications detectable by ultrasonography were classified as \u2018positive serology\u2019 subjects. Secretions of IL-5, IL-10 and interferon-gamma, and expression of IL-5 mRNA were evaluated in peripheral blood mononuclear cells (PBMC) stimulated in vitro with the mitogen phytohaemagglutinin-C or specific E. multilocularis antigenic preparations. The cytokine profile of abortive AE patients was the opposite of that observed in progressive AE patients. An intermediate profile was observed in positive serology subjects. PBMC from abortive AE patients, whether non-stimulated or stimulated with PHA and antigenic preparations, secreted significantly lower levels of IL-10 than those isolated from progressive AE patients. Our observations seem to confirm the regulatory role of IL-10 in the immunopathology of human AE.<\/jats:p>","DOI":"10.1046\/j.1365-2249.2000.01308.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:23:20Z","timestamp":1047378200000},"page":"484-490","source":"Crossref","is-referenced-by-count":56,"title":["Resistance\/susceptibility to <i>Echinococcus multilocularis<\/i> infection and cytokine profile in humans. I. Comparison of patients with progressive and abortive lesions"],"prefix":"10.1093","volume":"121","author":[{"given":"V","family":"Godot","sequence":"first","affiliation":[{"name":"WHO Collaborating Centre on Prevention and Treatment of Human Echinococcosis, Facult\u00e9 de M\u00e9decine et de Pharmacie, Besan\u00e7on Cedex"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Harraga","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre on Prevention and Treatment of Human Echinococcosis, Facult\u00e9 de M\u00e9decine et de Pharmacie, Besan\u00e7on Cedex"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Beurton","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre on Prevention and Treatment of Human Echinococcosis, Facult\u00e9 de M\u00e9decine et de Pharmacie, Besan\u00e7on Cedex"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Deschaseaux","sequence":"additional","affiliation":[{"name":"Blood Transfusion Centre of Franche-Comt\u00e9, Besan\u00e7on and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Sarciron","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology, Facult\u00e9 de Pharmacie, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Gottstein","sequence":"additional","affiliation":[{"name":"Institute of Parasitology, Universit\u00e4t Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D A","family":"Vuitton","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre on Prevention and Treatment of Human Echinococcosis, Facult\u00e9 de M\u00e9decine et de Pharmacie, Besan\u00e7on Cedex"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"2022011221080008800_b1","first-page":"61","article-title":"Cellular immune response in Echinococcus multilocularis infection in humans. 1) Lymphocyte reactivity to Echinococcus antigens in patients with alveolar echinococcosis","volume":"78","author":"Bresson-Hadni","year":"1989","journal-title":"Clin Exp Immunol"},{"key":"2022011221080008800_b2","first-page":"721","article-title":"Echinococcosis of the liver","volume-title":"Oxford textbook of clinical hepatology","author":"Miguet","year":"1990:"},{"key":"2022011221080008800_b3","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/0169-4758(95)80184-7","article-title":"Protective immune mechanisms against the metacestode of Echinococcus multilocularis","volume":"11","author":"Gottstein","year":"1995","journal-title":"Parasitol Today"},{"key":"2022011221080008800_b4","first-page":"247","article-title":"IgE-dependent humoral immune response in Echinococcus multilocularis infection: circulating and basophil-bound specific IgE against Echinococcus antigen in patients with alveolar echinococcosis","volume":"71","author":"Vuitton","year":"1988","journal-title":"Clin Exp Immunol"},{"key":"2022011221080008800_b5","first-page":"373","article-title":"Cellular immunity in experimental Echinococcus multilocularis infection. 2) Sequential and comparative phenotypic study of the periparasitic mononuclear cells in resistant and sensitive mice","volume":"82","author":"Bresson-Hadni","year":"1990","journal-title":"Clin Exp Immunol"},{"key":"2022011221080008800_b6","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1007\/BF01951932","article-title":"Experimental alveolar echinococcosis. 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