{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:36:07Z","timestamp":1792438567961,"version":"4.5.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,12,24]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>Differences have been shown between HLA characteristics of patients with different courses of alveolar echinococcosis (AE). Notably the HLA B8, DR3, DQ2 haplotype was associated with more severe forms of this granulomatous parasitic disease. We compared IL-10, IL-5, interferon-gamma (IFN-\u03b3) and tumour necrosis factor (TNF) secretion by peripheral blood mononuclear cells (PBMC) isolated from eight HLA-DR3+, DQ2+, B8+ AE patients and from 10 HLA-DR3\u2212, DQ2\u2212, B8\u2212 patients after non-specific mitogenic and specific Echinococcus multilocularis antigenic in vitro stimulation. PBMC from seven HLA-DR3+, DQ2+, B8+ healthy subjects and nine HLA-DR3\u2212, DQ2\u2212, B8\u2212 subjects were also studied as controls. PBMC from AE patients with HLA DR3+, DQ2+ haplotype secreted higher levels of IL-10 without any stimulation and after specific antigenic stimulation than did patients without this haplotype. Higher levels of IL-5 and IFN-\u03b3 were also produced by these patients' PBMC after stimulation with non-purified parasitic antigenic preparations; however, the specific alkaline phosphatase antigen extracted from E. multilocularis induced only Th2-type cytokine secretion. A spontaneous secretion of TNF by HLA DR3+, DQ2+ B8+ AE patients was also found. These results suggest that HLA characteristics of the host can influence immune-mediated mechanisms, and thus the course of AE in humans; specific antigenic components of E. multilocularis could contribute to the preferential Th2-type cytokine production favoured by the genetic background of the host.<\/jats:p>","DOI":"10.1046\/j.1365-2249.2000.01309.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T05:23:20Z","timestamp":1047360200000},"page":"491-498","source":"Crossref","is-referenced-by-count":69,"title":["Resistance\/susceptibility to\n                    <i>Echinococcus multilocularis<\/i>\n                    infection and cytokine profile in humans. II. Influence of the HLA B8, DR3, DQ2 haplotype"],"prefix":"10.1093","volume":"121","author":[{"given":"V","family":"Godot","sequence":"first","affiliation":[{"name":"WHO Collaborating Centre on Prevention and Treatment of Human Echinococcosis, Facult\u00e9 de M\u00e9decine et de Pharmacie, Besan\u00e7on Cedex"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Harraga","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre on Prevention and Treatment of Human Echinococcosis, Facult\u00e9 de M\u00e9decine et de Pharmacie, Besan\u00e7on Cedex"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Beurton","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre on Prevention and Treatment of Human Echinococcosis, Facult\u00e9 de M\u00e9decine et de Pharmacie, Besan\u00e7on Cedex"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Tiberghien","sequence":"additional","affiliation":[{"name":"Blood Transfusion Centre of Franche-Comt\u00e9, Besan\u00e7on and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Sarciron","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology, Facult\u00e9 de Pharmacie, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Gottstein","sequence":"additional","affiliation":[{"name":"Institute of Parasitology, Universit\u00e4t Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D A","family":"Vuitton","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre on Prevention and Treatment of Human Echinococcosis, Facult\u00e9 de M\u00e9decine et de Pharmacie, Besan\u00e7on Cedex"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"2022011221075986900_b1","first-page":"61","article-title":"Cellular immune response in Echinococcus multilocularis infection in humans. 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