{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:05:28Z","timestamp":1760907928886},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,10,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The role of interleukin (IL)-8 as mediator in the recruitment of leucocytes into the CSF was investigated during experimental pneumococcal meningitis. Rabbits were inoculated intracisternally with approximately 106 CFU Streptococcus pneumoniae, and treated (i) intravenously with 5 mg of a monoclonal antibody to IL-8 (n = 7) or 5 mg of an isotype control antibody (n = 6); (ii) intracisternally with anti-IL-8, 100 \u00b5g (n = 5), 10 \u00b5g (n = 4), 1 \u00b5g (n = 4), 0\u00b71 \u00b5g (n = 2). Ten rabbits served as untreated control group. Intravenous treatment with anti-IL-8 attenuated the pleocytosis significantly compared to untreated rabbits (P &amp;lt; 0\u00b704) or rabbits treated with an isotype control antibody (P &amp;lt; 0\u00b702). In contrast, intracisternal treatment with anti-IL-8 failed to attenuate the pleocytosis (P &amp;gt; 0\u00b705). These results show, that IL-8 plays an important role in the recruitment of leucocytes during experimental pneumococcal meningitis, and that the functional activity of IL-8 in this process appears to be on the bloodstream side of the microvascular endothelium of the brain.<\/jats:p>","DOI":"10.1046\/j.1365-2249.2000.01357.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:24:44Z","timestamp":1047378284000},"page":"207-211","source":"Crossref","is-referenced-by-count":24,"title":["Treatment with a monoclonal antibody to IL-8 attenuates the pleocytosis in experimental pneumococcal meningitis in rabbits when given intravenously, but not intracisternally"],"prefix":"10.1093","volume":"122","author":[{"given":"C","family":"\u00d8stergaard","sequence":"first","affiliation":[{"name":"Division of Microbiology, Department of Research and Development, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R V","family":"Yieng-Kow","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Department of Research and Development, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C G","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Marselisborg University Hospital, \u00c5rhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Mukaida","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Matsushima","sequence":"additional","affiliation":[{"name":"Department of Molecular Preventive Medicine, School of Medicine, University of Tokyo, Tokyo, 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