{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:21:22Z","timestamp":1791141682463,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,10,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Infection with Helicobacter pylori causes chronic active gastritis, which is characterized by neutrophils infiltrating the gastric epithelial layer and the underlying lamina propria as well as by T, B lymphocytes and macrophages accumulating in the lamina propria. In this study, the chemokine profile responsible for the recruitment of these inflammatory cells is investigated. Using both RNA\/RNA in situ hybridization and immunohistochemistry, the expression of the neutrophil and\/or lymphocyte-attractant CXC chemokines growth-related oncogene alpha (Gro\u03b1), IL-8, interferon-gamma (IFN-\u03b3)-inducible protein-10 (IP-10), monokine induced by IFN-\u03b3 (MIG) and the CC chemokines macrophage inflammatory protein-1\u03b1 (MIP-1\u03b1), -1\u03b2, regulated on activation normal T cell expressed and secreted (RANTES) and monocyte chemoattractant protein-1 (MCP-1) is studied and microanatomically localized in the gastric mucosa. Macrophages in the lamina propria at sites with neutrophil infiltration and gastric epithelium infiltrated by neutrophils highly expressed the neutrophil-attractant chemokines Gro\u03b1 and IL-8. Additionally, Gro\u03b1 and IL-8 were expressed by neutrophils themselves localized within gastric epithelium, in the foveolar lumen and in the cellular debris overlying mucosal erosion. IP-10 and to a lower extent MIG, both selectively chemotactic for inflammatory T cells, were expressed by endothelial cells of gastric mucosal vessels and by mononuclear cells at sites with T cell infiltration. Expression of all other CC chemokines tested was significantly lower. These in vivo data indicate that a set of predominantly CXC chemokines modulates the inflammation in H. pylori gastritis. Gro\u03b1 and IL-8 may play an important role in neutrophil trafficking from the mucosal vessel into the gastric epithelium, whereas IP-10 and MIG contribute to the recruitment of inflammatory T cells into the mucosa.<\/jats:p>","DOI":"10.1046\/j.1365-2249.2000.01374.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:24:44Z","timestamp":1047378284000},"page":"192-199","source":"Crossref","is-referenced-by-count":91,"title":["CXC chemokines Gro<i>\u03b1<\/i>\/IL-8 and IP-10\/MIG in<i>Helicobacter pylori<\/i>gastritis"],"prefix":"10.1093","volume":"122","author":[{"given":"M","family":"Eck","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Pathologie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Schmausser","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr 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