{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T22:44:11Z","timestamp":1775256251514,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,10,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The expression of CR2 (CD21) by synovial B and T lymphocytes of patients suffering from various forms of arthritis was analysed with cytofluorometry and with reverse transcriptase-polymerase chain reaction. CR2 (CD21) cell surface protein was detected in normal quantities on peripheral B cells, but was almost absent on synovial B lymphocytes of the same patients. This reduction was most severe in patients with rheumatoid arthritis, but also observed in all other cases. CR2 (CD21) did not reappear after in vitro culture. CR2 (CD21) mRNA was also strongly reduced in synovial B and T lymphocytes. Synovial fluid B lymphocytes were larger than peripheral blood B lymphocytes, while T cells from the same patients showed no size differences. We conclude that synovial fluid B lymphocytes have undergone an irreversible step towards terminal differentiation. The presence or absence of CR2 (CD21) mRNA in peripheral versus synovial T cells indicates that CR2 (CD21) is also differentially expressed by T lymphocytes.<\/jats:p>","DOI":"10.1046\/j.1365-2249.2000.01379.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:24:44Z","timestamp":1047378284000},"page":"270-276","source":"Crossref","is-referenced-by-count":27,"title":["Reduced expression of the complement receptor type 2 (CR2, CD21) by synovial fluid B and T lymphocytes"],"prefix":"10.1093","volume":"122","author":[{"given":"H","family":"Illges","sequence":"first","affiliation":[{"name":"Clinical Research Unit for Rheumatology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Braun","sequence":"additional","affiliation":[{"name":"Clinical Research Unit for Rheumatology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H H","family":"Peter","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Albert-Ludwigs-University Medical Centre, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Melchers","sequence":"additional","affiliation":[{"name":"Clinical Research Unit for Rheumatology and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,10,9]]},"reference":[{"key":"2022011221090548700_b1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0092-8674(00)81109-5","article-title":"Rheumatoid arthritis","volume":"85","author":"Feldmann","year":"1996","journal-title":"Cell"},{"key":"2022011221090548700_b2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"2022011221090548700_b3","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/art.1780370601","article-title":"Pannus and pannocytes. 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