{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:29:05Z","timestamp":1793424545137,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,12,24]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>L-selectin is a leucocyte adhesion molecule involved in leucocyte interactions with vascular endothelial cells. Following leucocyte activation L-selectin is endoproteolytically released from the cell surface. To assess whether psoriasis vulgaris results in systemic leucocyte activation, we examined expression levels of L-selectin on subsets of peripheral blood leucocytes from patients with psoriasis (n = 25) and normal control subjects. Serum levels of soluble L-selectin were quantified by ELISA in patients with psoriasis (n = 75), pustulosis palmaris et plantaris, and contact dermatitis, as well as normal control subjects. Psoriasis severity was evaluated by psoriasis area and severity index (PASI). L-selectin expression levels on CD4+ T cells, B cells, monocytes, and neutrophils from patients with severe-type psoriasis (PASI \u2265\u200a15) was significantly decreased compared with leucocytes from normal control subjects. Furthermore, L-selectin expression on CD4+ T cells showed good inverse correlation with PASI scores. Monocyte L-selectin expression was restored when the skin lesions of psoriasis were remitted. The frequencies of L-selectin+ CD4+ T cells or L-selectin+ CD8+ T cells from patients with psoriasis were almost normal. Serum L-selectin levels in patients with severe-type psoriasis were significantly higher than those in normal control subjects. These results suggest that subsets of leucocytes may be activated in psoriasis, and that L-selectin expression levels on some leucocyte subsets, especially CD4+ T cells, tend to correlate with disease severity of psoriasis.<\/jats:p>","DOI":"10.1046\/j.1365-2249.2000.01404.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:24:10Z","timestamp":1047378250000},"page":"484-492","source":"Crossref","is-referenced-by-count":18,"title":["Decreased expression levels of L-selectin on subsets of leucocytes and increased serum L-selectin in severe psoriasis"],"prefix":"10.1093","volume":"122","author":[{"given":"M","family":"Inaoki","sequence":"first","affiliation":[{"name":"Department of Dermatology, Kanazawa University School of Medicine, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kanazawa University School of Medicine, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kanazawa University School of Medicine, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Kawara","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kanazawa University School of Medicine, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D A","family":"Steeber","sequence":"additional","affiliation":[{"name":"Department of Immunology, Duke University Medical Center, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T F","family":"Tedder","sequence":"additional","affiliation":[{"name":"Department of Immunology, Duke University Medical Center, Durham, NC, 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