{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T15:18:38Z","timestamp":1720711118494},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,12,20]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The proliferative responses of T lymphocytes of a subset of patients with CVID are abnormally low. This may be due to abnormalities in extracellular interactions or signalling defects downstream from membrane-associated receptors. Demonstrating that the T cell receptor signalling was normal, we observed no abnormal pattern of activation-induced tyrosine phosphorylation in cells from CVID patients. Moreover, the addition of exogenous IL-2 increased the low proliferation to mitogens, thus indicating the integrity of the IL-2R signalling apparatus. Attractin is a rapidly expressed T cell activation antigen involved in forming an association between T cells and monocytes. Twenty-four to 48 h after activation by CD3 cross-linking, attractin expression was not up-regulated on the cells of CVID patients despite normal up-regulation of CD25 and CD26. On control cells, however, attractin expression was up-regulated together with CD25 and CD26. The addition of the purified 175-kD attractin was capable of restoring the proliferative response of peripheral blood mononuclear cells following CD3 X-L in the presence of suboptimal concentrations of rIL-2 (10 and 20 U\/ml). The effect was dose-dependent with the maximal effect at a concentration of 500 ng\/ml, and present at a concentration as low as 50 ng\/ml. Due to the likely role of attractin in cell guidance and amplification of the immune response, our results indicate that the lack of up-regulation of the molecule in patients with CVID may in turn affect any further step of productive immune response. Our finding may also imply a potential therapeutic role for this novel molecule.<\/jats:p>","DOI":"10.1046\/j.1365-2249.2001.01413.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:25:21Z","timestamp":1047378321000},"page":"99-104","source":"Crossref","is-referenced-by-count":25,"title":["Defective surface expression of attractin on T cells in patients with common variable immunodeficiency (CVID)"],"prefix":"10.1093","volume":"123","author":[{"given":"N","family":"Pozzi","sequence":"first","affiliation":[{"name":"Department of Paediatrics and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Gaetaniello","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Martire","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"De mattia","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Balestrieri","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Cosentini","sequence":"additional","affiliation":[{"name":"Immunohaematology Unit, \u2018Federico II\u2019 University, Naples and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S F","family":"Schlossman","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J S","family":"Duke-Cohan","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology and AIDS, Dana Farber 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