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Such an effect, though smaller, was also seen with heat-inactivated CMV, but only when triggered by zymosan. The effect was most pronounced in cells obtained from CMV antibody-negative donors. Dexamethasone further reduced the respiratory burst, both in uninfected and CMV-infected cells. Interferon-\u03b3 increased the response in uninfected cells and, to a lesser extend, in cells treated with heat-inactivated CMV, whereas no effect was seen with infective CMV. No overt productive infection or cytopathology could be detected, however, the monocytes incubated with infective but also heat-inactivated CMV formed clusters, a phenomenon that was equally pronounced in cultures from CMV antibody positive and negative-donors. These results might help explain the worse prognosis of P. carinii pneumonia in patients coinfected with CMV and receiving dexamethasone.<\/jats:p>","DOI":"10.1046\/j.1365-2249.2001.01465.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:25:28Z","timestamp":1047378328000},"page":"239-246","source":"Crossref","is-referenced-by-count":30,"title":["The impact of CMV on the respiratory burst of macrophages in response to<i>Pneumocystis carinii<\/i>"],"prefix":"10.1093","volume":"123","author":[{"given":"A L","family":"Laursen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S C","family":"Mogensen","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of Aarhus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H M K","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Aarhus Municipal Hospital, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P L","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Marselisborg Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ellermann-Eriksen","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of Aarhus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,12,20]]},"reference":[{"key":"2022011221101352400_b1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0002-9343(85)90334-1","article-title":"Spectrum of pulmonary diseases associated with the acquired immune deficiency syndrome","volume":"78","author":"Stover","year":"1985","journal-title":"Am J Med"},{"key":"2022011221101352400_b2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1148\/radiology.200.2.8685324","article-title":"Opportunistic bronchopulmonary infections after lung transplantation: clinical and radiographic findings","volume":"200","author":"Shreeniwas","year":"1996","journal-title":"Radiology"},{"key":"2022011221101352400_b3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1164\/ajrccm\/144.1.6","article-title":"Morbidity and mortality of patients with AIDS and first-episode Pneumocystis carinii pneumonia unaffected by concomitant pulmonary cytomegalovirus infection","volume":"144","author":"Jacobson","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"2022011221101352400_b4","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1378\/chest.107.3.595","article-title":"Associating poor outcome with the presence of cytomegalovirus in bronchoalveolar lavage from HIV patients with Pneumocystis carinii pneumonia","volume":"107","author":"Hyland","year":"1995","journal-title":"Chest"},{"key":"2022011221101352400_b5","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1378\/chest.108.2.411","article-title":"Does cytomegalovirus predict a poor prognosis in Pneumocystis carinii pneumonia treated with corticosteroids? 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