{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:06:07Z","timestamp":1793149567027,"version":"4.5.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,3,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Strongyloidiasis, a human intestinal infection caused by Strongyloides stercoralis (S. stercoralis), is difficult to cure with drugs. In particular, a decrease of the efficacy of treatment has been reported in patients dually infected with S. stercoralis and human T-cell leukaemia virus type I (HTLV-I), both of which are endemic in Okinawa, Japan. However, the factors influencing this resistance remain unclear. In the present study, patients infected with S. stercoralis, with or without HTLV-I infection, were treated with albendazole, followed up for one year and separated into two groups, cured and non-cured. The cure rate of S. stercoralis was lower in HTLV-I carriers (P &amp;lt; 0\u00b705). Serum levels of S. stercoralis-specific IgA, IgE, IgG, IgG1 and IgG4 antibodies were estimated, and a decrease of IgE (P &amp;lt; 0\u00b705) and an increase of IgG4 (P &amp;lt; 0\u00b705) were observed in the non-cured group, especially in HTLV-I carriers. RT-PCR of cytokines using peripheral blood mononuclear cells revealed that S. stercoralis patients with HTLV-I showed a high frequency of expression of IFN-\u03b3 and TGF-\u03b21, whereas those without HTLV-I showed no expression of these cytokines. IFN-\u03b3- and TGF-\u03b21-positive HTLV-I carriers showed a decrease of IgE (P &amp;lt; 0\u00b705), an increase of IgG4 (P &amp;lt; 0\u00b701) and a lower cure rate (P &amp;lt; 0\u00b701) compared with those who were negative for both cytokines. These results suggest that persistent infection with HTLV-I affected S. stercoralis-specific immunity and reduced therapeutic efficacy.<\/jats:p>","DOI":"10.1046\/j.1365-2249.2002.01733.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:30:43Z","timestamp":1047378643000},"page":"354-359","source":"Crossref","is-referenced-by-count":52,"title":["Reduced efficacy of treatment of strongyloidiasis in HTLV-I carriers related to enhanced expression of IFN-\u03b3 and TGF-\u03b21"],"prefix":"10.1093","volume":"127","author":[{"given":"M","family":"SATOH","sequence":"first","affiliation":[{"name":"Department of Medical Zoology, Saitama Medical School, Moroyama, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"TOMA","sequence":"additional","affiliation":[{"name":"Department of Parasitology, School of Medicine, University of the Ryukyus, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"SATO","sequence":"additional","affiliation":[{"name":"Department of Parasitology, School of Medicine, University of the Ryukyus, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"TAKARA","sequence":"additional","affiliation":[{"name":"Gushikawa Clinic, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"SHIROMA","sequence":"additional","affiliation":[{"name":"Izumizaki Hospital, Okinawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"KIYUNA","sequence":"additional","affiliation":[{"name":"Izumizaki Hospital, Okinawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"HIRAYAMA","sequence":"additional","affiliation":[{"name":"Department of Medical Zoology, Saitama Medical School, Moroyama, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,3,5]]},"reference":[{"key":"2022011300394911500_b1","first-page":"2849","article-title":"Human T-cell leukemia-lymphoma virus type 1 and adult T-cell leukemia-lymphoma in Okinawa.","volume":"45","author":"Clark","year":"1985","journal-title":"Cancer Res"},{"key":"2022011300394911500_b2","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/0020-7519(90)90045-O","article-title":"Application of enzyme-linked immunosorbent assay for mass examination of strongyloidiasis in Okinawa.","volume":"20","author":"Sato","year":"1990","journal-title":"Japan Int J Parasitol"},{"key":"2022011300394911500_b3","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0140-6736(85)92734-5","article-title":"Antibodies to human T lymphotropic virus type-I in patients with tropic spastic paraparesis.","volume":"2","author":"Gessain","year":"1985","journal-title":"Lancet"},{"key":"2022011300394911500_b4","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0140-6736(86)91298-5","article-title":"HTLV-I-associated myelopathy, a new clinical entity.","volume":"1","author":"Osame","year":"1986","journal-title":"Lancet"},{"key":"2022011300394911500_b5","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1073\/pnas.79.6.2031","article-title":"Isolation and characterization of retro-virus from cell lines of human adult T cell leukemia and its implication in the disease.","volume":"79","author":"Yoshida","year":"1982","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022011300394911500_b6","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1073\/pnas.81.8.2534","article-title":"Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease.","volume":"81","author":"Yoshida","year":"1984","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022011300394911500_b7","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0140-6736(84)91030-4","article-title":"High incidence of HTLV antibody in carriers of Strongyloides stercoralis","volume":"1","author":"Nakada","year":"1984","journal-title":"Lancet"},{"key":"2022011300394911500_b8","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/00002030-199206000-00009","article-title":"Seven years of recurrent severe strongyloidiasis in an HTLV-I infected man who developed adult T-cell leukaemia.","volume":"6","author":"Patey","year":"1992","journal-title":"AIDS"},{"key":"2022011300394911500_b9","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3109\/10428199309148542","article-title":"Six Colombian patients with adult T-cell leukemia\/lymphoma.","volume":"9","author":"Blank","year":"1993","journal-title":"Leuk Lymphoma"},{"key":"2022011300394911500_b10","doi-asserted-by":"crossref","first-page":"935","DOI":"10.11150\/kansenshogakuzasshi1970.66.935","article-title":"Clinical study of eradicated and resistant patients to treatment with ivermectin for strongyloidiasis.","volume":"66","author":"Shikiya","year":"1992","journal-title":"Kansenshogaku Zasshi"},{"key":"2022011300394911500_b11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0035-9203(94)90499-5","article-title":"Reduced efficacy of chemotherapy might accumulate concurrent HTLV-1 infection among strongyloidiasis patients in Okinawa","volume":"88","author":"Sato","year":"1994","journal-title":"Japan Trans R Soc Trop Med Hyg"},{"key":"2022011300394911500_b12","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1017\/S003118200007534X","article-title":"Immune-dependent chemotherapy of schistosomiasis.","volume":"105","author":"Fallon","year":"1992","journal-title":"Parasitology"},{"key":"2022011300394911500_b13","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/0002-9343(92)90113-P","article-title":"Strongyloides stercoralis: hyperinfection in a carrier of HTLV-I virus with evidence of selective immunosuppression.","volume":"92","author":"Newton","year":"1992","journal-title":"Am J Med"},{"key":"2022011300394911500_b14","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1093\/infdis\/169.3.692","article-title":"Immunoepidemiologic studies of Strongyloides stercoralis and human T lymphotropic virus type I infections in Jamaica.","volume":"169","author":"Robinson","year":"1994","journal-title":"J Infect Dis"},{"key":"2022011300394911500_b15","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1002\/eji.1830210815","article-title":"The human interferon-\u03b3 gene contains an inducible promoter that can be transactivated by tax I and II.","volume":"21","author":"Brown","year":"1991","journal-title":"Eur J Immunol"},{"key":"2022011300394911500_b16","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1084\/jem.172.1.121","article-title":"Transactivation of the transforming growth factor \u03b21 (TGF-\u03b21) gene by human T lymphotropic virus type 1 Tax: a potential mechanism for the increased production of TGF-\u03b21 in adult T cell leukemia.","volume":"172","author":"Kim","year":"1990","journal-title":"J Exp Med"},{"key":"2022011300394911500_b17","doi-asserted-by":"crossref","first-page":"6880","DOI":"10.1073\/pnas.85.18.6880","article-title":"IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons \u03b3 and \u03b1 and prostaglandin E2.","volume":"85","author":"Pene","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022011300394911500_b18","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/intimm\/4.3.397","article-title":"Modulation of IL-4 induced germline \u025b RNA synthesis in human B cells by tumor necrosis factor-\u03b1, anti-CD40 monoclonal antibodies or transforming growth factor-\u03b2 correlates with levels of IgE production.","volume":"4","author":"Gauchat","year":"1992","journal-title":"Int Immunol"},{"key":"2022011300394911500_b19","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0952-7915(05)80003-2","article-title":"Regulation of IgE synthesis by cytokines.","volume":"3","author":"Vries","year":"1991","journal-title":"Curr Opin Immunol"},{"key":"2022011300394911500_b20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0925-5710(96)00472-0","article-title":"Increased production of interferon \u03b3 but not interleukin 4 in human T-lymphotropic virus type I carriers.","volume":"64","author":"Shimamoto","year":"1996","journal-title":"Int J Hematol"},{"key":"2022011300394911500_b21","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1086\/314507","article-title":"Interferon-\u03b3 and interleukin-4 responses in relation to serum IgE levels in persons infected with human T lymphotropic virus type and Strongyloides stercoralis","volume":"178","author":"Neva","year":"1998","journal-title":"J Infect Dis"},{"key":"2022011300394911500_b22","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1006\/clin.1994.1147","article-title":"Virus production and spontaneous cell proliferation in HTLV-I-infected lymphocytes.","volume":"72","author":"Mann","year":"1994","journal-title":"Clin Immunol Immunopathol"},{"key":"2022011300394911500_b23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2149\/tmh1973.16.11","article-title":"A new method to detect Strongyloides stercoralis from human stool.","volume":"16","author":"Arakaki","year":"1988","journal-title":"Jpn J Trop Med Hyg"},{"key":"2022011300394911500_b24","doi-asserted-by":"crossref","first-page":"6476","DOI":"10.1073\/pnas.78.10.6476","article-title":"Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.","volume":"78","author":"Hinuma","year":"1981","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022011300394911500_b25","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1093\/infdis\/160.4.692","article-title":"Prominence of IgG4 antibodies in the human responses to Strongyloides stercoralis infection.","volume":"160","author":"Genta","year":"1989","journal-title":"J Infect Dis"},{"key":"2022011300394911500_b26","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/j.1348-0421.1987.tb03132.x","article-title":"Fluorometric enzyme-linked immunosorbent assay for the measurement of IgE antibody to mite Dermatophagoides farinae.","volume":"31","author":"Sakaguchi","year":"1987","journal-title":"Microbiol Immunol"},{"key":"2022011300394911500_b27","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1021\/bi00590a018","article-title":"Inhibition of intractable nucleases with ribonucleoside-vanadyl complexes: Isolation of messenger ribonucleic acid from resting lymphocytes.","volume":"18","author":"Berger","year":"1979","journal-title":"Biochemistry"},{"key":"2022011300394911500_b28","first-page":"676","article-title":"Immunologic and virologic characterization of the primary infiltrating cells in the aqueous humor of human T-cell leukemia virus type-1 uveitis.","volume":"38","author":"Ono","year":"1997","journal-title":"Invest Ophthalmol"},{"key":"2022011300394911500_b29","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/bjc.1998.687","article-title":"Transforming growth factor \u03b21 (TGF-\u03b21) is a preoperative prognostic indicator in advanced gastric carcinoma.","volume":"78","author":"Nakamura","year":"1998","journal-title":"Br J Cancer"},{"key":"2022011300394911500_b30","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0091-6749(98)70140-X","article-title":"Human mast cells produce IL-13 by high-affinity IgE receptor cross-linking: Enhanced IL-13 production by IL-4-primed human mast cells.","volume":"102","author":"Toru","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"2022011300394911500_b31","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1378\/chest.104.1.119","article-title":"Disseminated Strongyloides stercoralis in human immunodeficiency virus-infected patients. Treatment failure and a review of the literature.","volume":"104","author":"Lessnau","year":"1993","journal-title":"Chest"},{"key":"2022011300394911500_b32","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/ijc.2910310210","article-title":"Epstein-Barr virus-specific antibodies in patients with adult T-cell leukemia (ATL) and healthy ATL virus-carriers.","volume":"31","author":"Hinuma","year":"1983","journal-title":"Int J Cancer"},{"key":"2022011300394911500_b33","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/ijc.2910420605","article-title":"Suppression of tuberculin skin reaction in healthy HTLV-I carriers from Japan.","volume":"42","author":"Tachibana","year":"1988","journal-title":"Int J Cancer"},{"key":"2022011300394911500_b34","doi-asserted-by":"crossref","first-page":"574","DOI":"10.4269\/ajtmh.1988.38.574","article-title":"The immune response to nematode parasites: Modulation of mast cell numbers and function during Strongyloides stercoralis infections in nonhuman primates.","volume":"38","author":"Barrett","year":"1988","journal-title":"Am J Trop Med Hyg"},{"key":"2022011300394911500_b35","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/349243a0","article-title":"Human IgE, IgG4 and resistance to reinfection with Schistosoma haematobium.","volume":"349","author":"Hagan","year":"1991","journal-title":"Nature"},{"key":"2022011300394911500_b36","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.4049\/jimmunol.145.12.4298","article-title":"Filarial-specific IgG4 response correlates with active Wuchereria bancrofti infection.","volume":"145","author":"Kwan-lim","year":"1990","journal-title":"J Immunol"},{"key":"2022011300394911500_b37","first-page":"263","article-title":"Monitoring of specific IgG4 antibodies in respiratory allergy due to the pollen of Parietaria judaica. Evidence for a protective role.","volume":"24","author":"Panzani","year":"1996","journal-title":"Allergol Immunopathol"},{"key":"2022011300394911500_b38","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S1081-1206(10)62995-X","article-title":"Immunologic changes during immunotherapy in asthmatic children: increased IL-13 and allergen-specific IgG4 antibody levels.","volume":"80","author":"Lu","year":"1998","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2022011300394911500_b39","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1002\/eji.1830220816","article-title":"Strong serum inhibition of specific IgE correlated to competing IgG4, revealed by a new methodology in subjects from a S. mansoni endemic area.","volume":"22","author":"Rihet","year":"1992","journal-title":"Eur J Immunol"},{"key":"2022011300394911500_b40","doi-asserted-by":"crossref","first-page":"6880","DOI":"10.1073\/pnas.85.18.6880","article-title":"IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferon \u03b3 and \u03b1 and prostaglandin E2.","volume":"85","author":"Pene","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022011300394911500_b41","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/0091-6749(94)90256-9","article-title":"Regulation of IgE and IgG4 responses by allergen specific T-cell clones to bee venom phospholipase A2 in vitro.","volume":"93","author":"Carballido","year":"1994","journal-title":"J Allergy Clin Immunol"},{"key":"2022011300394911500_b42","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0091-6749(97)70052-6","article-title":"Induction and differential regulation of bee venom phospholipase A2-specific human IgE and IgG4 antibodies in vitro requires allergen-specific and nonspecific activation of T and B cells.","volume":"99","author":"Akdis","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"2022011300394911500_b43","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1002\/eji.1830211037","article-title":"Interferon-\u03b3 inhibits serotonin release from mouse peritoneal mast cells.","volume":"21","author":"Coleman","year":"1991","journal-title":"Eur J Immunol"},{"key":"2022011300394911500_b44","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.4049\/jimmunol.159.3.1444","article-title":"Nitric oxide inhibits IgE-mediated degranulation of mast cells and is the principal intermediate in IFN-\u03b3-induced suppression of exocytosis.","volume":"159","author":"Eastmond","year":"1997","journal-title":"J Immunol"},{"key":"2022011300394911500_b45","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/intimm\/4.3.397","article-title":"Modulation of IL-4 induced jermline \u025b RNA synthesis in human B cells by tumor necrosis factor-\u03b1, anti-CD40 monoclonal antibodies or transforming growth factor-\u03b2 correlates with levels of IgE production.","volume":"4","author":"Gauchat","year":"1992","journal-title":"Int Immunol"},{"key":"2022011300394911500_b46","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.4049\/jimmunol.153.5.2194","article-title":"Transforming growth factor-\u03b2 prevents stem cell factor-mediated rescue of mast cells from apoptosis after IL-3 deprivation.","volume":"153","author":"Mekori","year":"1994","journal-title":"J Immunol"},{"key":"2022011300394911500_b47","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1165\/ajrcmb.16.3.9070612","article-title":"TGF-\u03b21 inhibits the release of histamine and tumor necrosis factor-\u03b1 from mast cells through an autocrine pathway.","volume":"16","author":"Bissonnette","year":"1997","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2022011300394911500_b48","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-3024.1980.tb00040.x","article-title":"Histopathological changes following primary, secondary and repeated infections of rats with Strongyloides ratti, with special reference to tissue eosinophils.","volume":"2","author":"Moqbel","year":"1980","journal-title":"Parasite Immunol"},{"key":"2022011300394911500_b49","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/icb.1983.59","article-title":"The location of antigenic sites on the surface of the nematode parasite Strongyloides ratti reactive to antibody-directed cellular cytotoxicity from both macrophages and eosinophils from the natural host.","volume":"61","author":"Tam","year":"1983","journal-title":"Aust J Exp Biol Med Sci"},{"key":"2022011300394911500_b50","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1006\/expr.1995.1036","article-title":"Strongyloides stercoralis: Protective immunity to third-stage larvae in Balb\/cByJ mice.","volume":"80","author":"Abraham","year":"1995","journal-title":"Exp Parasitol"},{"key":"2022011300394911500_b51","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1081-1206(10)62968-7","article-title":"Long-term therapy with recombinant interferon-gamma (rIFN-\u03b3) for atopic dermatitis.","volume":"80","author":"Schneider","year":"1998","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2022011300394911500_b52","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1093\/intimm\/11.6.1001","article-title":"Th1-derived cytokine IFN-\u03b3 is a potent inhibitor of eotaxin synthesis in vitro.","volume":"11","author":"Miyamasu","year":"1999","journal-title":"Int Immunol"},{"key":"2022011300394911500_b53","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1084\/jem.179.3.1041","article-title":"Transforming growth factor \u03b2 abrogates the effects of hematopoietins on eosinophils and induces their apoptosis.","volume":"179","author":"Alam","year":"1994","journal-title":"J Exp Med"},{"key":"2022011300394911500_b54","doi-asserted-by":"crossref","first-page":"4454","DOI":"10.4049\/jimmunol.155.9.4454","article-title":"Mechanism of inhibition of eosinophil activation by transforming growth factor-\u03b2.","volume":"155","author":"Pazdrak","year":"1995","journal-title":"J Immunol"},{"key":"2022011300394911500_b55","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/0140-6736(91)91631-4","article-title":"Decreased eosinophil numbers in HTLV-I carriers","volume":"337","author":"Welles","year":"1991","journal-title":"Lancet"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2249.2002.01733.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2249.2002.01733.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/127\/2\/354\/42137933\/j.1365-2249.2002.01733.x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/127\/2\/354\/42137933\/j.1365-2249.2002.01733.x.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T20:33:51Z","timestamp":1682109231000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/127\/2\/354\/6478540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2]]},"references-count":55,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2002,3,5]]},"published-print":{"date-parts":[[2002,3,5]]}},"URL":"https:\/\/doi.org\/10.1046\/j.1365-2249.2002.01733.x","relation":{},"ISSN":["1365-2249","0009-9104"],"issn-type":[{"value":"1365-2249","type":"electronic"},{"value":"0009-9104","type":"print"}],"subject":[],"published-other":{"date-parts":[[2002,2]]},"published":{"date-parts":[[2002,2]]}}}