{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:25:45Z","timestamp":1785320745971,"version":"3.55.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,5,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n               <jats:p>The aetiology of chronic prostatitis is not understood. The aim of this study is to investigate an autoimmune hypothesis by looking for T cell proliferation in response to proteins of the seminal plasma. We studied peripheral blood mononuclear cell proliferation from 20 patients with chronic prostatitis and 20 aged-matched controls in response to serial dilutions of seminal plasma (SP) from themselves (autologous SP) and from a healthy individual without the disease (allo-SP). We found that the patients have a statistically greater lymphocyte proliferation to autologous SP at the 1\/50 dilution on day 6 compared to controls (P = 0\u00b701). They also have a greater proliferation to allo-SP on both day 5 (P = 0\u00b7001) and day 6 (P = 0\u00b701) at the same dilution. Using a stimulation index (SI) of 9 to either autologous SP or allo-SP on day 6 at the 1\/50 dilution as a definition of a proliferative response to SP, then 13\/20 patients as compared to 3\/20 controls showed a proliferative response to SP (P = 0\u00b7003, Fisher's exact test). These data support an autoimmune hypothesis for chronic prostatitis.<\/jats:p>","DOI":"10.1046\/j.1365-2249.2002.01853.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:31:51Z","timestamp":1047378711000},"page":"302-307","source":"Crossref","is-referenced-by-count":61,"title":["Autoimmune T cell responses to seminal plasma in chronic pelvic pain syndrome (CPPS)"],"prefix":"10.1093","volume":"128","author":[{"given":"G R D","family":"BATSTONE","sequence":"first","affiliation":[{"name":"Department of Urology, Addenbrooke's Hospital, Cambridge, UK"},{"name":"Cambridge University Department of Rheumatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"DOBLE","sequence":"additional","affiliation":[{"name":"Department of Urology, Addenbrooke's Hospital, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J S H","family":"GASTON","sequence":"additional","affiliation":[{"name":"Cambridge University Department of Rheumatology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,5,2]]},"reference":[{"key":"2022011221431646100_b1","volume-title":"National Institute of Diabetes and Digestive and Kidney Diseases Workshop on Chronic Prostatitis: Summary Statement.","author":"National Institutes of Health (NIH)","year":"1995"},{"key":"2022011221431646100_b2","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0090-4295(98)00172-1","article-title":"Prevalence of bothersome genitourinary symptoms and diagnoses in younger men on routine primary care visits","volume":"52","author":"Collins","year":"1998","journal-title":"Urology"},{"key":"2022011221431646100_b3","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/S0022-5347(01)63564-X","article-title":"How common is prostatitis? 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