{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:54:40Z","timestamp":1790319280978,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2002,10,17]],"date-time":"2002-10-17T00:00:00Z","timestamp":1034812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,10,17]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Although \u200aT \u200acell \u200ainvolvement \u200ain \u200aHelicobactor \u200apylori-induced \u200agastritis \u200ais \u200aknown, \u200amechanism \u200aabout \u200aT cell recruitment is not understood. In this study we examined how mucosal addressin cell adhesion \u00admolecule-1 (MAdCAM-1) is involved in lymphocyte recruitment in murine chronic gastritis induced by H. pylori. C57 BL\/6 mice were infected with Sydney strain (SS1). Six months after infection, the stomach was removed. The expression of adhesion molecules, MAdCAM-1, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), and the cell surface antigens CD4, CD8, CD45R\/B220 or \u03b27-integrin were determined by immunohistochemistry. A significant increase in CD4 lymphocytes was observed in the body portion of stomach in SS1-infected mice and most of these CD4 cells express \u03b27-integrin, a known counter ligand for MAdCAM-1 molecule. Strong MAdCAM-1 expression was observed adjacent to these cells in the lamina propria as well as in the submucosa of SS1-infected stomach. Quantitative analysis showed that the area of MAdCAM-1 expression well correlated with the infiltration of \u03b27-integrin positive lymphocytes. On the other hand, expression of ICAM-1 or VCAM-1 in the lamina propria was few even in the SS1-infected stomach. Increased expression of MAdCAM-1 was well correlated to the location of lymphocytes, which express CD4 and \u03b27-integrin. These results suggest the possibility that MAdCAM-1 may be largely involved in the lymphocyte recruitment in the gastritis mucosa with H. pylori.<\/jats:p>","DOI":"10.1046\/j.1365-2249.2002.01984.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T05:33:48Z","timestamp":1047360828000},"page":"183-189","source":"Crossref","is-referenced-by-count":20,"title":["Increased expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and lymphocyte recruitment in murine gastritis induced by\n                    <i>Helicobacter pylori<\/i>"],"prefix":"10.1093","volume":"130","author":[{"given":"K","family":"HATANAKA","sequence":"first","affiliation":[{"name":"Second Department of Internal Medicine, National Defense Medical College, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"HOKARI","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, National Defense Medical College, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"MATSUZAKI","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, National Defense Medical College, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"KATO","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, National Defense Medical College, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"KAWAGUCHI","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, National Defense Medical College, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"NAGAO","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, National Defense Medical College, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"SUZUKI","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"MIYAZAKI","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Saitama Hospital, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"SEKIZUKA","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Saitama Hospital, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"NAGATA","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Keio University, Tokyo, 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