{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:21:54Z","timestamp":1780582914296,"version":"3.54.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2003,4,16]],"date-time":"2003-04-16T00:00:00Z","timestamp":1050451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,4,16]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>HIV1-gp160 holds promises in anti-HIV vaccinal strategies. However, this molecule has been described to exhibit superantigenic activities. The present study aimed at examining the effect(s) of HIV1-gp160 on human B cells and in particular on B cells originating from HIV\u2013 donors. We purified human B cells of various origins, i.e. from blood and from tonsils (representing a mucosal-type origin), and we tested these cells (stimulated with a polyclonal B cell activator, interleukin (IL)-2 and IL-10 as cytokines, and recombinant HIV1-gp160) for the production of IgG and IgA in an in vitro model. Gp160 induced significantly less total IgG by blood\u2003\u2212\u2003but not tonsil-originating\u2003\u2212\u2003B cells and did not affect total IgA production. Further, HIV1-gp160 up-regulated IL-2-, IL-4- and IL-10-mRNA levels in stimulated blood B cells (these cytokines are known to be active on B cell activation and differentiation). Interestingly, HIV1-gp160 also up-regulated IL-1\u03b2-, transforming growth factor (TGF)-\u03b2-, interferon (IFN)-\u03b3- and IL-12-mRNA levels in stimulated mucosal-type, tonsil-originating, B cells. As these latter cytokines are involved in proinflammatory activities, HIV-gp160 delivery at the mucosal sites would be compatible with an adjuvant activity.<\/jats:p>","DOI":"10.1046\/j.1365-2249.2003.02152.x","type":"journal-article","created":{"date-parts":[[2004,12,21]],"date-time":"2004-12-21T21:52:06Z","timestamp":1103665926000},"page":"304-308","source":"Crossref","is-referenced-by-count":8,"title":["HIV-gp160 modulates differentially the production<i>in vitro<\/i>of IgG, IgA and cytokines by blood and tonsil B lymphocytes from HIV-negative individuals"],"prefix":"10.1093","volume":"132","author":[{"given":"F","family":"COGNASSE","sequence":"first","affiliation":[{"name":"GIMAP-EA3064 and \u2021Centre Commun de Cytom\u00e9trie en Flux, Universit\u00e9 de Saint-Etienne, Facult\u00e9 de M\u00e9decine, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"B\u00c9NIGUEL","sequence":"additional","affiliation":[{"name":"GIMAP-EA3064 and \u2021Centre Commun de Cytom\u00e9trie en Flux, Universit\u00e9 de Saint-Etienne, Facult\u00e9 de M\u00e9decine, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"El HABIB","sequence":"additional","affiliation":[{"name":"Aventis Pasteur, Marcy l'Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"SABIDO","sequence":"additional","affiliation":[{"name":"EFS Auvergne-Loire, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"CHAVARIN","sequence":"additional","affiliation":[{"name":"EFS Auvergne-Loire, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"GENIN","sequence":"additional","affiliation":[{"name":"GIMAP-EA3064 and \u2021Centre Commun de Cytom\u00e9trie en Flux, Universit\u00e9 de Saint-Etienne, Facult\u00e9 de M\u00e9decine, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"GARRAUD","sequence":"additional","affiliation":[{"name":"GIMAP-EA3064 and \u2021Centre Commun de Cytom\u00e9trie en Flux, Universit\u00e9 de Saint-Etienne, Facult\u00e9 de M\u00e9decine, Saint-Etienne, France"},{"name":"EFS Auvergne-Loire, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,4,16]]},"reference":[{"key":"2022011222102454600_b1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1146\/annurev.immunol.20.081501.094854","article-title":"Prospects for vaccine protection against HIV-1 infection and AIDS","volume":"20","author":"Letvin","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"2022011222102454600_b2","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1073\/pnas.94.4.1356","article-title":"Identification of the B cell superantigen-binding site of HIV-1 gp120","volume":"94","author":"Karray","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022011222102454600_b3","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1097\/00002030-199907300-00008","article-title":"Compartmentalization of the IgG immune response to HIV-1 in breast milk","volume":"13","author":"Becquart","year":"1999","journal-title":"Aids"},{"key":"2022011222102454600_b4","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1097\/00002030-200009080-00006","article-title":"Mucosal and plasma IgA from HIV-exposed seronegative individuals neutralize a primary HIV-1 isolate","volume":"14","author":"Devito","year":"2000","journal-title":"Aids"},{"key":"2022011222102454600_b5","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1086\/315420","article-title":"Neutralization of human immunodeficiency virus type 1 (HIV-1) mediated by parotid IgA of HIV-1-infected patients","volume":"181","author":"Moja","year":"2000","journal-title":"J Infect Dis"},{"key":"2022011222102454600_b6","first-page":"S22","article-title":"[Indications for adenoidectomy and\/or tonsillectomy in children. 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