{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:25:38Z","timestamp":1787955938071,"version":"build-2784847793"},"reference-count":75,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":571,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,6]]},"DOI":"10.1046\/j.1365-2257.2000.00301.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T12:16:39Z","timestamp":1047384999000},"page":"133-143","source":"Crossref","is-referenced-by-count":51,"title":["Hyperhomocysteinemia and thrombosis"],"prefix":"10.1111","volume":"22","author":[{"given":"M.","family":"Makris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB25|cit1","first-page":"9858","article-title":"Plasma homocysteine assay in the exploration of thrombosis in young subjects","volume":"20","author":"Bienvenu","year":"1991","journal-title":"Presse Med"},{"issue":"Suppl. 2","key":"10.1046\/j.1365-2257.2000.00301.x-BIB45|cit2","first-page":"S31","article-title":"Mutated 5,10-methylenetetrahydrofolate reductase and moderate hyperhomocysteinaemia","volume":"157","author":"Blom","year":"1998","journal-title":"European Journal of Pediatrics"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB10|cit3","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1055\/s-0038-1657580","article-title":"Hyperhomocysteinemia as a risk factor for arterial and venous disease. A review of evidence and relevance","volume":"78","author":"Boers","year":"1997","journal-title":"Thrombosis and Haemostasis"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB32|cit4","first-page":"167","article-title":"Plasma homocyst (e) ine concentrations in pregnant and non-pregnant women with controlled folate intake","volume":"92","author":"Bonnette","year":"1999","journal-title":"Obstetrics and Gynecology"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB23|cit5","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1161\/01.ATV.17.11.2554","article-title":"Elevated fasting total homocysteine levels and cardiovascular disease outcomes in maintenance dialysis patients. A prospective study","volume":"17","author":"Bostom","year":"1997","journal-title":"Arteriosclerosis Thrombosis and Vascular Biology"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB19|cit6","doi-asserted-by":"crossref","first-page":"352","DOI":"10.7326\/0003-4819-131-5-199909070-00006","article-title":"Nonfasting plasma total homocysteine levels and stroke incidence in elderly persons: The Framingham study","volume":"131","author":"Bostom","year":"1999","journal-title":"Annals of Internal Medicine"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB17|cit7","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/jama.1995.03530130055028","article-title":"A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intake","volume":"274","author":"Boushey","year":"1995","journal-title":"Journal of the American Medical Association"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB26|cit8","first-page":"517","article-title":"Plasma homocysteine in venous thromboembolism","volume":"21","author":"Brattstrom","year":"1991","journal-title":"Haemostasis"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB44|cit9","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1161\/01.CIR.98.23.2520","article-title":"Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the results of a meta-analysis","volume":"98","author":"Brattstrom","year":"1998","journal-title":"Circulation"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB1|cit10","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1136\/adc.37.195.505","article-title":"Metabolic abnormalities detected in a survey of mentally backward individuals in Ireland","volume":"37","author":"Carson","year":"1962","journal-title":"Archives of Diseases of Childhood"},{"issue":"Suppl.","key":"10.1046\/j.1365-2257.2000.00301.x-BIB9|cit11","first-page":"S21","article-title":"Fasting plasma homocysteine levels do not predict the occurrence of deep vein thrombosis after elective hip replacement surgery","volume":"52","author":"Cattaneo","year":"1998","journal-title":"Netherlands Journal of Medicine"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1055\/s-0037-1614438","article-title":"Hyperhomocysteinemia, atherosclerosis and thrombosis","volume":"81","author":"Cattaneo","year":"1999","journal-title":"Thrombosis and Haemostasis"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB62|cit13","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0140-6736(05)78090-9","article-title":"Acute hyperhomocysteinaemia and endothelial dysfunction","volume":"351","author":"Chambers","year":"1998","journal-title":"Lancet"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB51|cit14","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1056\/NEJM199104253241701","article-title":"Hyperhomocysteinemia: an independent risk factor for vascular disease","volume":"324","author":"Clarke","year":"1991","journal-title":"New England Journal of Medicine"},{"issue":"Suppl. 1","key":"10.1046\/j.1365-2257.2000.00301.x-BIB58|cit15","first-page":"528","article-title":"A hypercoagulable state in homocystinuria due to homozygous cystathionine \u03b2-synthase deficiency","volume":"78","author":"Coppola","year":"1997","journal-title":"Thrombosis and Haemostasis"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB11|cit16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V90.1.1","article-title":"Homocysteine and thrombotic disease","volume":"90","author":"D'Angelo","year":"1997","journal-title":"Blood"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB34|cit17","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1111\/j.1471-0528.1997.tb10970.x","article-title":"Hyperhomocysteinemia and protein S deficiency in complicated pregnancies","volume":"104","author":"De Vries","year":"1997","journal-title":"British Journal of Obstetrics and Gynecology"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB27|cit18","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1055\/s-0037-1615380","article-title":"Hyperhomocysteinemia and venous thrombosis: a meta-analysis","volume":"80","author":"Den Heijer","year":"1998","journal-title":"Thrombosis and Haemostasis"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB60|cit19","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1172\/JCI116715","article-title":"Abnormally high thromboxane biosynthesis in homozygous homocystinuria - Evidence for platelet involvement and probucol-sensitive mechanism","volume":"92","author":"Di Minno","year":"1993","journal-title":"Journal of Clinical Investigation"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB30|cit20","first-page":"566","article-title":"Hyperhomocysteinemia is a risk factor of recurrent venous thromboembolism","volume":"80","author":"Eichinger","year":"1998","journal-title":"Thrombosis and Haemostasis"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB15|cit21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.7326\/0003-4819-131-5-199909070-00008","article-title":"Homocyst (e) ine and cardiovascular disease: a critical review of the epidemiological evidence","volume":"131","author":"Eikelboom","year":"1999","journal-title":"Annals of Internal Medicine"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB50|cit22","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/0024-3205(95)02009-8","article-title":"Oral administration of homocysteine leads to increased plasma triglycerides and homocysteic acid - additional mechanisms in homocysteine induced endothelial damage","volume":"57","author":"Frauscher","year":"1995","journal-title":"Life Sciences"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB40|cit23","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase","volume":"10","author":"Frosst","year":"1995","journal-title":"Nature Genetics"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB37|cit24","first-page":"1052","article-title":"Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype\/phenotype correlations in severe ethylenetetrahydrofolate reductase deficiency","volume":"56","author":"Goyette","year":"1995","journal-title":"American Journal of Human Genetics"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB52|cit25","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1203\/00006450-198206000-00018","article-title":"Effect of homocysteine and homocystine on platelet and vascular arachidonic acid metabolism","volume":"16","author":"Graeber","year":"1982","journal-title":"Pediatric Research"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB18|cit26","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1001\/jama.1997.03540460039030","article-title":"Plasma homocysteine as a risk factor for vascular disease","volume":"277","author":"Graham","year":"1997","journal-title":"Journal of the American Medical Association"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB5|cit27","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1093\/jn\/124.10.1934","article-title":"Plasma concentrations of homocysteine and other aminothiol compounds are related to food intake in healthy subjects","volume":"124","author":"Guttormsen","year":"1994","journal-title":"Journal of Nutrition"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB69|cit28","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0140-6736(98)11058-9","article-title":"Homocysteine and vascular disease","volume":"354","author":"Hankey","year":"1999","journal-title":"Lancet"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB46|cit29","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1056\/NEJM197409122911101","article-title":"Homocysteinemia, vascular injury and arterial thrombosis","volume":"291","author":"Harker","year":"1974","journal-title":"New England Journal of Medicine"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB47|cit30","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1172\/JCI108520","article-title":"The role of endothelial cell injury and platelet response in its genesis","volume":"58","author":"Harker","year":"1976","journal-title":"Journal of Clinical Investigation"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB70|cit31","doi-asserted-by":"crossref","first-page":"818.","DOI":"10.1056\/NEJM197704072961415","article-title":"Platelets in homocystinuria","volume":"296","author":"Harker","year":"1977","journal-title":"New England Journal of Medicine"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB75|cit32","doi-asserted-by":"crossref","first-page":"10193","DOI":"10.1073\/pnas.89.21.10193","article-title":"Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein (a) to fibrin: a potential biochemical link between thrombosis, atherogenesis and sulfhydryl compound metabolism.","volume":"89","author":"Harpel","year":"1992","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB56|cit33","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1056\/NEJM198209233071303","article-title":"Kinetics and distribution of indium-labelled platelets in patients with homocystinuria","volume":"307","author":"Hill-Zobel","year":"1982","journal-title":"New England Journal of Medicine"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB64|cit34","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1136\/bmj.316.7135.894","article-title":"Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials","volume":"316","author":"Homocysteine Lowering Trialists' Collaboration (","year":"1998","journal-title":"British Medical Journal of"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB68|cit35","doi-asserted-by":"crossref","first-page":"348","DOI":"10.7326\/0003-4819-131-5-199909070-00005","article-title":"Normalization of hyperhomocysteinemia with L-Thyroxine in hypothyroidism","volume":"131","author":"Hussein","year":"1999","journal-title":"Annals of Internal Medicine"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB42|cit36","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/01.CIR.93.1.7","article-title":"Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations","volume":"93","author":"Jacques","year":"1996","journal-title":"Circulation"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB67|cit37","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1056\/NEJM199905133401901","article-title":"The effect of folic acid fortification on plasma folate and total homocysteine concentrations","volume":"340","author":"Jacques","year":"1999","journal-title":"New England Journal of Medicine"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB38|cit38","first-page":"414","article-title":"Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase","volume":"43","author":"Kang","year":"1988","journal-title":"American Journal of Human Genetics"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB39|cit39","first-page":"536","article-title":"Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease","volume":"48","author":"Kang","year":"1991","journal-title":"American Journal of Human Genetics"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB20|cit40","doi-asserted-by":"crossref","first-page":"321","DOI":"10.7326\/0003-4819-131-5-199909070-00002","article-title":"Nonfasting plasma total homocysteine level and mortality in middle aged and elderly men and women in Jerusalem","volume":"131","author":"Kark","year":"1999","journal-title":"Annals of Internal Medicine"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB59|cit41","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1055\/s-0038-1665405","article-title":"Levels of prothrombin fragment 1+2 in patients with hyperhomocysteinemia and a history of venous thromboembolism","volume":"78","author":"Kyrle","year":"1997","journal-title":"Thrombosis and Haemostasis"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB53|cit42","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1182\/blood.V81.3.683.683","article-title":"Homocysteine inhibits von Willebrand factor processing and secretion by preventing transport from the endoplasmic reticulum","volume":"81","author":"Lentz","year":"1993","journal-title":"Blood"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB57|cit43","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1172\/JCI118771","article-title":"Vascular dysfunction in monkeys with diet induced hyperhomocysteinemia","volume":"98","author":"Lentz","year":"1996","journal-title":"Journal of Clinical Investigation"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB65|cit44","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1056\/NEJM199804093381501","article-title":"Reduction of plasma homocysteine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease","volume":"338","author":"Malinow","year":"1998","journal-title":"New England Journal of Medicine"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB13|cit45","first-page":"111","article-title":"Vascular pathology of homocysteinemia: implications for the pathogenesis of atherosclerosis","volume":"56","author":"McCully","year":"1969","journal-title":"American Journal of Pathology"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB71|cit46","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0021-9150(75)90004-0","article-title":"Homocysteine theory of arteriosclerosis","volume":"22","author":"McCully","year":"1975","journal-title":"Atherosclerosis"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB2|cit47","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1126\/science.143.3613.1443","article-title":"Homocystinuria: an enzymatic defect","volume":"143","author":"Mudd","year":"1964","journal-title":"Science"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB8|cit48","first-page":"1","article-title":"The natural history of homocystinuria due to cystathionine beta- synthase deficiency","volume":"37","author":"Mudd","year":"1985","journal-title":"American Journal of Human Genetics"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB24|cit49","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1161\/01.CIR.97.2.138","article-title":"Prospective study of hyperhomocysteinemia as an adverse cardiovascular risk factor in end stage renal disease","volume":"20","author":"Mustapha","year":"1998","journal-title":"Circulation"},{"issue":"Suppl. 2","key":"10.1046\/j.1365-2257.2000.00301.x-BIB7|cit50","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1007\/PL00014310","article-title":"Newborn screening for homocystinuria: Irish and world experience","volume":"157","author":"Naughten","year":"1998","journal-title":"European Journal of Pediatrics"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB21|cit51","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM199707243370403","article-title":"Plasma homocysteine levels and mortality in patients with coronary artery disease","volume":"337","author":"Nygard","year":"1997","journal-title":"New England Journal of Medicine"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB66|cit52","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1056\/NEJM199804093381509","article-title":"Eat right and take a multivitamin","volume":"338","author":"Oakley","year":"1998","journal-title":"New England Journal of Medicine"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB72|cit53","first-page":"395","volume-title":"Hypercoagulable States","author":"Palareti","year":"1996"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB22|cit54","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/S0140-6736(96)03032-2","article-title":"Plasma homocysteine as a risk factor for atherothrombotic events in systemic lupus erythematosus","volume":"348","author":"Petri","year":"1996","journal-title":"Lancet"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB3|cit55","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1093\/clinchem\/45.1.152","article-title":"Method comparison for total homocysteine between the Abbott IMx analyser and an HPLC assay with internal standardization","volume":"45","author":"Pfeiffer","year":"1999a","journal-title":"Clinical Chemistry"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB4|cit56","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1093\/clinchem\/45.8.1261","article-title":"Comparison of plasma total homocysteine measurements in 14 laboratories: an international study","volume":"45","author":"Pfeiffer","year":"1999b","journal-title":"Clinical Chemistry"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB36|cit57","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0140-6736(96)04125-6","article-title":"Increased fetal loss in women with heritable thrombophilia","volume":"348","author":"Preston","year":"1997","journal-title":"Lancet"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB33|cit58","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0029-7844(97)00223-8","article-title":"Elevated homocysteine levels with preeclampsia","volume":"90","author":"Rajkovic","year":"1997","journal-title":"Obstetrics and Gynecology"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB28|cit59","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1001\/archinte.158.19.2101","article-title":"Meta-analysis of hyperhomocysteinemia as a risk factor for venous thromboembolic disease","volume":"158","author":"Ray","year":"1998","journal-title":"Archives of Internal Medicine"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB29|cit60","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1161\/01.CIR.95.7.1777","article-title":"Interrelation of hyperhomocyst (e) inemia, factor V Leiden, and risk of future venous thromboembolism","volume":"95","author":"Ridker","year":"1997","journal-title":"Circulation"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB55|cit61","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1182\/blood.V75.4.895.895","article-title":"Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells","volume":"75","author":"Rodgers","year":"1990","journal-title":"Blood"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB54|cit62","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1172\/JCI112519","article-title":"Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator","volume":"77","author":"Rodgers","year":"1986","journal-title":"Journal of Clinical Investigation"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB41|cit63","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1055\/s-0038-1657581","article-title":"Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR)","volume":"78","author":"Rozen","year":"1997","journal-title":"Thrombosis and Haemostasis"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB43|cit64","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.nutr.19.1.217","article-title":"Homocysteine metabolism","volume":"19","author":"Selhub","year":"1999","journal-title":"Annual Review of Nutrition"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB48|cit65","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1172\/JCI116187","article-title":"Adverse vascular effects of homocysteine are modulated by endothelium derived relaxing factor and related oxides of nitrogen","volume":"91","author":"Stamler","year":"1993","journal-title":"Journal of Clinical Investigation"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB74|cit66","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1172\/JCI112442","article-title":"Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine","volume":"77","author":"Starkebaum","year":"1986","journal-title":"Journal of Clinical Investigation"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB35|cit67","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/0026-0495(94)90004-3","article-title":"Maternal hyperhomocysteinemia: a risk factor for neural tube defects?","volume":"43","author":"Steegers-Theunissen","year":"1994","journal-title":"Metabolism"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB6|cit68","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1136\/jcp.51.3.183","article-title":"Clinical implications of plasma homocysteine measurement in cardiovascular disease","volume":"51","author":"Still","year":"1998","journal-title":"Journal of Clinical Pathology"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB61|cit69","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1161\/01.CIR.95.5.1119","article-title":"Hyperhomocyst (e) inemia is associated with impaired endothelium dependent vasodilation in humans","volume":"95","author":"Tawakol","year":"1997","journal-title":"Circulation"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB49|cit70","doi-asserted-by":"crossref","first-page":"6369","DOI":"10.1073\/pnas.91.14.6369","article-title":"Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis","volume":"91","author":"Tsai","year":"1994","journal-title":"Proceedings of the National Academy of Science USA"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB73|cit71","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1136\/pgmj.72.851.513","article-title":"Homocystinuria: what about mild hyperhomocysteinaemia?","volume":"72","author":"Van Den","year":"1996","journal-title":"Postgraduate Medical Journal of"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB31|cit72","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0002-9378(99)70269-3","article-title":"Changes in homocysteine levels during normal pregnancy","volume":"180","author":"Walker","year":"1999","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB14|cit73","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1056\/NEJM199804093381507","article-title":"Homocysteine and atherosclerosis","volume":"338","author":"Welch","year":"1998","journal-title":"New England Journal of Medicine"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB16|cit74","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1172\/JCI108350","article-title":"The pathogenesis of coronary artery disease","volume":"57","author":"Wilcken","year":"1976","journal-title":"Journal of Clinical Investigation"},{"key":"10.1046\/j.1365-2257.2000.00301.x-BIB63|cit75","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1016\/S0735-1097(99)00469-6","article-title":"Folic acid improves endothelial-dependent vasodilation in hyperhomocysteinemia","volume":"34","author":"Woo","year":"1999","journal-title":"Journal of the American College of Cardiologists"}],"container-title":["Clinical & Laboratory Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2257.2000.00301.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2257.2000.00301.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1046\/j.1365-2257.2000.00301.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T17:57:05Z","timestamp":1602611825000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1046\/j.1365-2257.2000.00301.x"}},"subtitle":["Hyperhomocysteinemia and Thrombosis"],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":75,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,6]]}},"URL":"https:\/\/doi.org\/10.1046\/j.1365-2257.2000.00301.x","archive":["Portico"],"relation":{},"ISSN":["0141-9854"],"issn-type":[{"value":"0141-9854","type":"print"}],"subject":[],"published":{"date-parts":[[2000,6]]}}}