{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T18:18:17Z","timestamp":1700417897091},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,1,4]],"date-time":"2002-01-04T00:00:00Z","timestamp":1010102400000},"content-version":"vor","delay-in-days":1221,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[1998,9]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>This study was designed to test the hypothesis that hypothalamic hamartoma causes precocious puberty through a different neuroendocrine mechanism than that of normal puberty or of idiopathic precocious puberty.<\/jats:p><\/jats:sec><jats:sec><jats:title>DESIGN AND PATIENTS<\/jats:title><jats:p>We compared the pattern of gonadotrophin secretion among 4 girls with precocious puberty due to hypothalamic hamartoma, 27 girls with idiopathic precocious puberty, and 14 girls with normal puberty. All subjects were breast stage 3 or 4. Blood samples were obtained every 20\u2003min for 4\u2003h during the day (1.000 hours to 1400\u2003h) and night (22.00 hours to 0200\u2003h).<\/jats:p><\/jats:sec><jats:sec><jats:title>MEASUREMENTS<\/jats:title><jats:p>LH, FSH, and prolactin were measured in each blood sample. Girls also underwent LHRH\u2010stimulation with measurement of LH and FSH before and after stimulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>There were no significant differences in mean LH level, LH peak amplitude, or LH or FSH peak frequency during either the day or the night among the three diagnostic groups. However, the mean\u2003\u00b1\u2003SD LHRH\u2010stimulated peak LH levels were greater in girls with hypothalamic hamartoma than in girls with normal puberty or with idiopathic precocious puberty (194\u2003\u00b1\u2003142 <jats:italic>vs<\/jats:italic> 85\u2003\u00b1\u200360 or 66\u2003\u00b1\u200354 IU\/l, respectively, <jats:italic>P\u2003<\/jats:italic>&lt; 0.05). The LHRH\u2010stimulated peak FSH level in girls with hypothalamic hamartoma exceeded the level for the normal pubertal girls (31\u2003\u00b1\u200319 <jats:italic>vs<\/jats:italic> 17\u2003\u00b1\u20037 IU\/l, <jats:italic>P\u2003<\/jats:italic>&lt; 0.05), but not the level for the girls with idiopathic precocious puberty (25\u2003+ 12 IU\/l). The peak LH to peak FSH ratio in the girls with hypothalamic hamartoma exceeded the ratio for the girls with idiopathic precocious puberty (7.3\u2003\u00b1\u20033.9 <jats:italic>vs<\/jats:italic> 2.6\u2003\u00b1\u20033.0\u2003IU\/l, <jats:italic>P\u2003<\/jats:italic>&lt;\u20030.05), but not the ratio for the normal pubertal girls (5.0\u2003+\u20032.9). There were no significant differences in mean prolactin level, peak amplitude or frequency, or in the ratio of mean night to mean day prolactin, among the 3 diagnostic groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>We conclude that spontaneous gonadotrophin and prolactin secretion are similar among girls with hypothalamic hamartoma, idiopathic precocious puberty, or normal puberty. However, the increased LHRH\u2010stimulated peak LH in the girls with hypothalamic hamartoma suggests subtle differences in neuroendocrine regulation that may underlie their more rapid pubertal maturation.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1365-2265.1998.00518.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:38:26Z","timestamp":1047379106000},"page":"363-368","source":"Crossref","is-referenced-by-count":5,"title":["Gonadotrophin and prolactin secretory dynamics in girls with normal puberty, idiopathic precocious puberty and precocious puberty due to hypothalamic hamartoma"],"prefix":"10.1111","volume":"49","author":[{"given":"M. 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