{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T19:46:31Z","timestamp":1774467991977,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,1,4]],"date-time":"2002-01-04T00:00:00Z","timestamp":1010102400000},"content-version":"vor","delay-in-days":1191,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Non\u2010tumour causes of hyperprolactinaemia, including prolactin\u2010elevating drugs, must be excluded. There is a general view that such drugs are unlikely to raise serum PRL above 3000\u2003mU\/l, but the literature is confusing. We report 8 patients receiving treatment with neuroleptic drugs, whose serum PRL concentrations were grossly elevated.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Prolactin was measured using a 2\u2010site immunofluorometric assay (Abbott Laboratories; reference range &lt;\u2003500\u2003mU\/l). Seven of the eight women (age range 24\u201349 years) were symptomatic (galactorrhoea, oligo\u2010 or amenorrhoea).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Prolactin concentrations ranged from 3600\u2003mU\/l to 7300\u2003mU\/l. All patients had a normal pituitary CT scan. Five patients were treated with bromocriptine without detriment to their mental state.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Prolactin can rise to concentrations associated with prolactinomas in patients on neuroleptic drugs. As it is rarely possible to stop the drugs to see if the PRL concentration will decline to normal, neuroradiology is required in these patients to exclude a vision\u2010threatening macroprolactinoma before deciding on medical treatment.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1365-2265.1998.00569.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:38:26Z","timestamp":1047379106000},"page":"513-516","source":"Crossref","is-referenced-by-count":29,"title":["Serum prolactin concentration in patients taking neuroleptic drugs"],"prefix":"10.1111","volume":"49","author":[{"given":"Anne","family":"Pollock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. H.","family":"McLaren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,1,4]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-351X(05)80094-1"},{"key":"e_1_2_5_3_2","first-page":"173","article-title":"Effect of bromocriptine mesylate on induced hyperprolactinaemia in stabilized psychiatric outpatients undergoing neuroleptic treatment","volume":"13","author":"Cohn J.B.","year":"1985","journal-title":"Pharmacopsychiatry"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/000456327901600126"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1976.tb01953.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245440"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(18)30442-0"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/000456328602300603"},{"key":"e_1_2_5_9_2","first-page":"851","article-title":"Management of psychotropic\u2010induced hyperprolactinaemia","volume":"11","author":"Marken P.A.","year":"1992","journal-title":"Clinical Pharmacy"},{"key":"e_1_2_5_10_2","first-page":"639","article-title":"Effects of bromocriptine on neuroleptic\u2010induced amenorrhoea, galactorrhoea and impotence","volume":"40","author":"Matsuoka I.","year":"1986","journal-title":"Japanese Journal of Psychiatry and Neurology"},{"key":"e_1_2_5_11_2","first-page":"737","article-title":"Neuroleptic\u2010associated hyperprolactinaemia. Can it be treated with bromocriptine","volume":"37","author":"Smith S.","year":"1992","journal-title":"Journal of Reproductive Medicine"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000119265"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2265.1998.00569.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2265.1998.00569.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2265.1998.00569.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T23:07:09Z","timestamp":1698448029000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2265.1998.00569.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["10.1046\/j.1365-2265.1998.00569.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2265.1998.00569.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,10]]}}}