{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:18:52Z","timestamp":1792207132195,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T00:00:00Z","timestamp":1214611200000},"content-version":"vor","delay-in-days":3070,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Complications of childhood cirrhosis include abnormal growth and malnutrition, associated with abnormalities in circulating IGFs and IGFBPs. Controlled studies suggest that intensive enteral feeding enhances nutritional status. The aim was to ascertain whether nasogastric feeding improves nutritional status in clinical practice and to assess the effect of feeding on serum IGF\u2010I and IGFBPs.<\/jats:p><\/jats:sec><jats:sec><jats:title>PATIENTS<\/jats:title><jats:p>Thirty\u2010three children (median age 0.6 years) with biliary atresia and failure to thrive who were treated with nasogastric feeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>MEASUREMENTS<\/jats:title><jats:p>Height, weight and triceps skin fold thickness were measured prior to feeding and regularly for 1 year or until feeding was stopped. Serum IGF\u2010I and IGFBPs were measured by immunoassay at the same intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The median duration of feeding was 3.7 months. Twenty\u2010two stopped feeding after liver transplantation, while 10 stopped electively and 1 boy died. Before feeding, the children were losing weight and height centile. Triceps skin fold thickness, weight and height <jats:sc>sd <\/jats:sc>scores improved with feeding. Baseline serum IGF\u2010I and IGFBP\u20103 were low, while IGFBP\u20101 and IGFBP\u20102 were raised. IGF\u2010I and IGFBP\u20101 did not change with feeding. IGFBP\u20102 fell and reached a nadir by 3 months, while IGFBP\u20103 rose temporarily for 4\u20136 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Nasogastric feeding improves body composition in paediatric liver disease but circulating IGF\u2010I and IGFBPs remain abnormal and do not play a major role in mediating these changes. This does not exclude a paracrine or autocrine effect of IGF\u2010I.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1365-2265.2000.00934.x","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:00:47Z","timestamp":1027677647000},"page":"217-224","source":"Crossref","is-referenced-by-count":35,"title":["Nasogastric feeding enhances nutritional status in paediatric liver disease but does not alter circulating levels of IGF\u2010I and IGF binding proteins"],"prefix":"10.1111","volume":"52","author":[{"given":"Richard","family":"Holt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Miell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgina","family":"Mieli\u2010Vergani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,6,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.5.603"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/56.1.158"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840210313"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.1.160"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/65.2.534"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","unstructured":"Holt R.I.G. Teale J.D. Jones J.S. Quin J.D. McGregor A.M.&Miell J.P.(1997b)Gene expression and serum levels of insulin\u2010like growth factors (IGFs) and IGF binding proteins in a case of non\u2010islet cell tumour hypoglycaemia.Growth Regulation April (on\u2010line journal).","DOI":"10.1016\/S1096-6374(98)80297-9"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(96)00407-8"},{"key":"e_1_2_6_9_2","first-page":"239","article-title":"Nutritional therapy in patients with liver cirrhosis","volume":"46","author":"Kondrup J.","year":"1992","journal-title":"European Journal of Clinical Nutrition"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19970024"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199102000-00013"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(90)90390-U"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.12.7088"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-66-2-266"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-15-1-80"},{"key":"e_1_2_6_16_2","article-title":"Energy and protein requirements. 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