{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T08:40:19Z","timestamp":1794472819637,"version":"4.9.1"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":663,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Elevated blood pressure (BP) is an important predictor of morbidity and mortality from cardiovascular disease. Patients with Turner syndrome (TS) have a higher morbidity and mortality in middle age than the normal population. As BP in childhood or early adulthood is predictive of BP later in adult life, we assessed manual and 24\u2003h ambulatory BP in patients with TS to determine whether the BP pattern is altered at an early stage in these patients who are known to be at risk of cardiovascular disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS AND METHODS<\/jats:title>\n                    <jats:p>We studied manual and 24\u2003h ambulatory BP profiles in 75 girls with Turner syndrome, age range 5.4\u201322.4\u2003years. A monitor with an oscillometric device (SpaceLabs model 90207) and an appropriate sized cuff was used. BP was measured during the day\u2010time (0800\u20132000\u2003h) and the night\u2010time periods (2200\u20130800\u2003h). The BP measured were compared with population standards. The effect of different growth promoting agents on BP was also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Mean manual and 24\u2003h ambulatory BP measurements were 118\/77\u2003mmHg (range 95\/60\u2013140\/102) and 115\/70\u2003mmHg (range 93\/57\u2013154\/99), respectively. There was minimal difference between the two methods with a positive bias of 2.4\u2003mmHg for diastolic BP and a negative bias of 2.1\u2003mmHg for systolic BP. The mean standard deviation scores (SDS) corresponding to the mean BP recordings were 24\u2003h systolic +\u20030.81 (range \u2212\u20031.26 to +\u20034.45), 24\u2003h diastolic +\u20030.43 (range \u2212\u20030.85 to +\u20033.42), day\u2010time systolic +\u20031.08 (range \u2212\u20030.95 to +\u20034.72), day\u2010time diastolic +\u20030.70 (range \u2212\u20030.94 to +\u20033.71), night\u2010time systolic +\u20030.22 (range \u22122.2 to +\u20033.64) and night\u2010time diastolic \u2212\u20030.18 (range \u22122.0 to +\u20032.43). The SDS for both the mean 24\u2003h and day\u2010time systolic and diastolic BP were shifted to the right of the normal distribution. 57% of the girls had less than the normal 10% reduction in nocturnal systolic blood pressure. 17% had diastolic and 21% had systolic blood pressure above the 95th percentile for age and sex. There was no significant difference in the BP SDS between girls on no treatment and those receiving treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Over 50% of girls with Turner syndrome have an abnormal BP circadian rhythm, which is similar to adult patients with secondary hypertension. Patients with Turner syndrome have higher blood pressure measurements compared to published population standards, as evidenced by the shift to the right of both the systolic and diastolic BP SDS. These findings suggest that girls with Turner syndrome should be carefully monitored in childhood and adulthood for blood pressure and other cardiovascular risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1046\/j.1365-2265.2000.00960.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T05:44:27Z","timestamp":1047361467000},"page":"363-370","source":"Crossref","is-referenced-by-count":105,"title":["Blood pressure and Turner syndrome"],"prefix":"10.1111","volume":"52","author":[{"family":"Nathwani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Unwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Brook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Hindmarsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80001-4"},{"key":"e_1_2_6_3_2","first-page":"S25","article-title":"Can secondary hypertension be identified by twenty\u2010four\u2010hour ambulatory blood pressure monitoring?","volume":"7","author":"Baumgart P.","year":"1989","journal-title":"Journal of Hypertension"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_6_5_2","first-page":"S13","article-title":"Circadian rhythm and blood pressure control: physiological and pathophysiological factors","volume":"12","author":"Coca A.","year":"1994","journal-title":"Journal of Hypertension"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.68.3.470"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1542\/peds.72.4.459","article-title":"Validity of mass blood pressure screening in children","volume":"72","author":"Fixler D.E.","year":"1983","journal-title":"Pediatrics"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.73.1.17"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(97)00237-0"},{"key":"e_1_2_6_10_2","first-page":"20","article-title":"Primary prevention trials and the rationale for treating mild hypertension","volume":"9","author":"Grimm R.H.","year":"1987","journal-title":"Clinical Therapeutics"},{"key":"e_1_2_6_11_2","unstructured":"Hall J.G.(1990) The management of the adult with Turner syndrome. The natural history of Turner syndrome. In:Turner syndrome (eds. R. G. Rosenfeld & M. Grumbach) pp.495510. Marcel Dekker New York."},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03450030078036"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365519309092556"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.69.2.242"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.18.3_Suppl.I74"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)38478-4"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.307.6917.1451"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199412000-00002"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80700-4"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0022-5347(17)57322-X","article-title":"The association of significant renal anomalies with Turner's syndrome","volume":"120","author":"Litvak A.S.","year":"1978","journal-title":"Journal of Urology"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992287101001006"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90878-9"},{"key":"e_1_2_6_23_2","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1093\/ajh\/1.4.366S","article-title":"Beyond blood pressure control: effect of antihypertensive therapy on cardiovascular risk factors","volume":"1","author":"Maxwell M.H.","year":"1988","journal-title":"American Journal of Hypertension"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1983.tb03192.x"},{"key":"e_1_2_6_25_2","unstructured":"McCrory W.W.(1992) Definition prevalence and distribution of causes of hypertension. 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