{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:08:45Z","timestamp":1787004525090,"version":"build-2736575974"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":510,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2000,8]]},"abstract":"\n OBJECTIVE<\/jats:title>\n Serum calcium was found to be an independent, prospective risk factor for myocardial infarction. We have previously shown that altered arterial reactivity in the course of primary hyperparathyroidism, a disease characterized by hypercalcaemia, may predominantly involve the arterial media and not the endothelium as observed in patients with various stages of atherosclerosis. The present study was performed to test whether successful parathyroidectomy can improve vascular reactivity in patients with primary hyperparathyroidism.<\/jats:p>\n <\/jats:sec>\n \n SUBJECTS AND DESIGN<\/jats:title>\n Endothelium\u2010dependent, flow\u2010mediated and endothelium\u2010independent, nitroglycerin\u2010induced dilatation were assessed by brachial artery ultrasound (7\u2003MHz) in 18 patients with primary hyperparathyroidism (mean\u2003\u00b1\u2003SD; age, 55.1\u2003\u00b1\u200312.6) prior to and 3 years after successful parathyroidectomy.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Parathyroidectomy resulted in significant decreases of PTH (242\u2003\u00b1\u2003186\n vs<\/jats:italic>\n . 34\u2003\u00b1\u200324\u2003ng\/l,\n P<\/jats:italic>\n \u2003= 0.0001) and serum calcium levels (2.8\u2003\u00b1\u20030.3\n vs<\/jats:italic>\n . 2.4\u2003\u00b1 0.1\u2003mm\/l,\n P<\/jats:italic>\n \u2003=\u20030.00001) and in an increase of serum phosphate levels (0.78\u2003\u00b1\u20030.23\n vs<\/jats:italic>\n . 1.17\u2003\u00b1\u20030.18\u2003mm\/l,\n P<\/jats:italic>\n \u2003=\u20030.00001). However, normalization of hormone and electrolyte levels did not lead to an improvement of flow\u2010mediated dilatation (12.1\u2003\u00b1\u20033.1\n vs<\/jats:italic>\n . 11.0\u2003\u00b1\u20035.4&,\n P<\/jats:italic>\n \u2003=\u20030.49) or nitroglycerin\u2010induced dilatation (12.5\u2003\u00b1 3.1\n vs<\/jats:italic>\n . 13.2\u2003\u00b1\u20036.8%,\n P<\/jats:italic>\n \u2003=\u20030.68) within the follow\u2010up period. No changes were observed with respect to the risk factor profile, vessel size and blood flow.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n These data suggest that restoration of normocalcaemia by parathyroidectomy cannot improve vascular reactivity in patients with primary hyperparathyroidism but may prevent further progression of vascular disease within this period of time.<\/jats:p>\n <\/jats:sec>","DOI":"10.1046\/j.1365-2265.2000.01076.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T05:45:55Z","timestamp":1047361555000},"page":"229-233","source":"Crossref","is-referenced-by-count":26,"title":["Effects of successful parathyroidectomy on altered arterial reactivity in patients with hypercalcaemia: results of a 3\u2010year follow\u2010up study"],"prefix":"10.1111","volume":"53","author":[{"given":"Thomas","family":"Neunteufl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Heher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Prager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhold","family":"Katzenschlager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudette","family":"Abela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Niederle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Stefenelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2265.2000.01076.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2265.2000.01076.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2265.2000.01076.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T05:31:22Z","timestamp":1698557482000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2265.2000.01076.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["10.1046\/j.1365-2265.2000.01076.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2265.2000.01076.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8]]}}}