{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:17:20Z","timestamp":1791281840129,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":479,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) is a cytokine with numerous immunological and metabolic activities. In addition, TNF\u2010\u03b1 can stimulate a variety of physiological, neuroendocrine and behavioural responses of the central nervous system. In experimental animals, TNF\u2010\u03b1 induces changes in physiological and behavioural parameters which have also been observed in eating disorders. The biological activities of TNF\u2010\u03b1 are mediated by two structurally related, but functionally distinct receptors, TNF\u2010RI and TNF\u2010RII. Since injection of TNF\u2010\u03b1 results in increased shedding of TNF\u2010\u03b1 receptors, it is likely that TNF\u2010\u03b1 release is reflected by soluble TNF\u2010receptors (sTNF\u2010Rs) levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>AIMS<\/jats:title><jats:p>We studied plasma concentrations of TNF\u2010\u03b1 and two sTNF\u2010Rs (sTNF\u2010RI and sTNF\u2010RII) in female patients with bulimia nervosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>DESIGN AND PATIENTS<\/jats:title><jats:p>Twenty female patients with bulimia nervosa (BN) and 20 age\u2010matched normal women (N) were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>MEASUREMENTS<\/jats:title><jats:p>Plasma TNF\u2010\u03b1 concentrations were measured by enzyme immunoassay kit and plasma concentrations of sTNF\u2010RI and sTNF\u2010RII were measured by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Plasma TNF\u2010\u03b1 concentrations in BN were significantly higher than those in N (4.7\u2003\u00b1\u20030.5\u2003ng\/l <jats:italic>vs<\/jats:italic>. 1.6\u2003\u00b1\u20030.1\u2003ng\/l; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01). Although no significant difference was observed in plasma sTNF\u2010RI concentrations between the two groups, plasma sTNF\u2010RII concentrations in BN were significantly higher than those in N (2080.0\u2003\u00b1\u2003107.5\u2003ng\/l <jats:italic>vs<\/jats:italic>. 1569.5\u2003\u00b1\u200384.0\u2003ng\/l; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01). Plasma TNF\u2010\u03b1 concentrations were significantly related to plasma sTNF\u2010RI concentrations (<jats:italic>r<\/jats:italic>\u2003=\u20030.511, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) and to plasma sTNF\u2010RII concentrations (<jats:italic>r<\/jats:italic>\u2003=\u20030.532, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) in bulimic patients. However, plasma TNF\u2010\u03b1 concentrations were not related to body fat mass or to bulimic behaviours in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Our present findings suggest that the adipose tissue may not be the immediate source of TNF\u2010\u03b1 in bulimic patients but the increase in plasma TNF\u2010\u03b1 in these patients may be derived from the central nervous system sources. The elevated sTNF\u2010RII may reflect different shedding kinetics compared with sTNF\u2010RI in bulimic patients.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1365-2265.2000.01091.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:46:24Z","timestamp":1047379584000},"page":"383-388","source":"Crossref","is-referenced-by-count":29,"title":["Plasma concentrations of tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) and soluble TNF receptors in patients with bulimia nervosa"],"prefix":"10.1111","volume":"53","author":[{"given":"Yoshikatsu","family":"Nakai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Hamagaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuro","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ataru","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Kurimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI694"},{"key":"e_1_2_6_3_2","unstructured":"1994).Diagnostic and Statistical Manual of Mental Disorders. 4th edn American Psychiatric Press Washington. 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