{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T18:24:06Z","timestamp":1697567046228},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,1,12]],"date-time":"2002-01-12T00:00:00Z","timestamp":1010793600000},"content-version":"vor","delay-in-days":286,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:p>PTHrP has been found in various tissues, including prolactinomas and growth hormone producing adenomas. The function and clinical importance of PTHrP are poorly understood.<\/jats:p><jats:p>We report the case of a 25\u2010year\u2010old female patient with hirsutism. Autonomous ACTH\u2010dependent hypercortisolism was documented by endocrine testing. Magnetic resonance imaging (MRI) revealed a 3\u2010mm intrasellar hypointense lesion in the left side of the pituitary gland. The inferior petrosal sinus sampling disclosed a gradient of ACTH left central\/peripheral of 30\u00b75 and right central\/peripheral of 2\u00b70 and suggested the diagnosis of a left\u2010sided pituitary ACTH secreting microadenoma.<\/jats:p><jats:p>Interestingly, we found elevated PTHrP levels in the left inferior petrosal sinus with a gradient of 4\u00b77 compared to peripheral venous blood and of 3\u00b76 compared to the right sinus.<\/jats:p><jats:p>Our results fit very well to the concept of a para\u2010\/autocrine secretion of PTHrP which has been proposed recently and suggest a role in the regulation of cell growth of pituitary adenomas.<\/jats:p>","DOI":"10.1046\/j.1365-2265.2001.01101.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:48:44Z","timestamp":1047379724000},"page":"555-557","source":"Crossref","is-referenced-by-count":3,"title":["Elevated inferior petrosal sinus levels of PTHrP in a patient with Cushing's disease"],"prefix":"10.1111","volume":"54","author":[{"given":"G.","family":"H\u00f6fle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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