{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:53:20Z","timestamp":1783482800180,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,1,12]],"date-time":"2002-01-12T00:00:00Z","timestamp":1010793600000},"content-version":"vor","delay-in-days":286,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:p>A 31\u2010year\u2010old woman presented with neutropenia due to thionamide drug therapy for Graves' disease. She also reported 8\u2003weeks of amenorrhoea and had a positive pregnancy test. Her drug therapy was discontinued and her neutropenia resolved uneventfully. The hyperthyroidism recurred a week later. After consideration of all treatment options, it was decided to observe until 14\u2003weeks when an elective thyroidectomy was planned. Mother and fetus were monitored closely and both tolerated moderate hyperthyroidism well. At 14\u2003weeks the patient underwent a total thyroidectomy after rendering her euthyroid with a short course of sodium ipodate. Labour was induced at 41\u2003weeks. Delivery was complicated by fetal distress and precipitated a forceps delivery. A 3250\u2003g male infant was born with poor Apgar score and required 2\u2003h of ventilation. At 1\u2003year, the child had reached all developmental milestones at appropriate times.<\/jats:p><jats:p>Both mother and fetus may tolerate moderate thyrotoxicosis well in early pregnancy, an alternative that should be considered when thionamide drug therapy is contraindicated.<\/jats:p>","DOI":"10.1046\/j.1365-2265.2001.01111.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:48:44Z","timestamp":1047379724000},"page":"559-561","source":"Crossref","is-referenced-by-count":16,"title":["Management of a pregnant patient with Graves' disease complicated by thionamide\u2010induced neutropenia in the first trimester"],"prefix":"10.1111","volume":"54","author":[{"given":"S.","family":"Davison","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. W. 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