{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:30:58Z","timestamp":1790803858197,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,7,7]],"date-time":"2008-07-07T00:00:00Z","timestamp":1215388800000},"content-version":"vor","delay-in-days":2744,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p>OBJECTIVE\u2003To examine the factors influencing the levels of sex hormone\u2010binding globulin (SHBG) in normal postmenopausal women by assessing the relationship between SHBG and measured anthropometric, metabolic and hormonal variables.<\/jats:p><jats:p>DESIGN\u2003Cross\u2010sectional, observational study.<\/jats:p><jats:p>SUBJECTS and METHODS\u2003Seventy normal postmenopausal women aged 47\u201371\u2003years (mean 58\u2003years), participated in the study. Information was collected on medical, reproductive and smoking history, alcohol use, dietary intake and physical activity. Body composition measurements using dual\u2010energy absorptiometry, and analyses of biochemical and hormonal indices were performed.<\/jats:p><jats:p>RESULTS\u2003Bivariate correlation coefficients indicated that SHBG was inversely related to body weight (<jats:italic>r<\/jats:italic>\u2003=\u2003\u2212\u20030\u00b744), fat mass (<jats:italic>r<\/jats:italic>\u2003=\u2003\u2212\u20030\u00b735), and abdominal obesity (<jats:italic>r<\/jats:italic>\u2003=\u2003\u2212\u20030\u00b742). It was also inversely related to the glucose and insulin levels during an oral glucose tolerance test (\u2212\u20030\u00b724\u2003&lt;\u2003<jats:italic>r<\/jats:italic>\u2003&lt;\u2003\u2212\u20030\u00b740), serum oestradiol (<jats:italic>r<\/jats:italic>\u2003=\u2003\u2212\u20030\u00b726), and physical activity (<jats:italic>r<\/jats:italic>\u2003=\u2003\u2212\u20030\u00b724). Multiple regression analysis indicated that significant independent correlates of SHBG concentration were fat mass, physical activity, alcohol intake, serum oestradiol, and insulin\u2010like growth factor\u20101, all having a negative impact on SHBG.<\/jats:p><jats:p>CONCLUSIONS\u2003From these observed associations, it is concluded that maintenance of body weight, moderate alcohol consumption, and physical activity will tend to reduce SHBG concentrations in postmenopausal women, thereby increasing the levels of free oestradiol. This mechanism could mediate the beneficial effects of these factors in preventing the development of osteoporosis and cardiovascular disease.<\/jats:p>","DOI":"10.1046\/j.1365-2265.2001.01183.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:47:45Z","timestamp":1047379665000},"page":"81-87","source":"Crossref","is-referenced-by-count":34,"title":["Determinants of sex hormone\u2010binding globulin in normal postmenopausal women"],"prefix":"10.1111","volume":"54","author":[{"given":"Fiona","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Ames","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret C.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John 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