{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:29:07Z","timestamp":1774686547374,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,20]],"date-time":"2001-12-20T00:00:00Z","timestamp":1008806400000},"content-version":"vor","delay-in-days":322,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Children with \u03b2\u2010thalassaemia major (\u03b2\u2010thal) frequently have growth retardation in the presence of low serum IGF\u2010I and a normal GH response to pharmacological stimulation suggesting that they have GH insensitivity (GHIS). This study was carried out to study the cause of their growth retardation.<\/jats:p><\/jats:sec><jats:sec><jats:title>DESIGN<\/jats:title><jats:p>We studied IGF\u2010I and IGFBP\u20103 generation after exogenous GH administration for four days, in 15 prepubertal controls (C) and 41 prepubertal \u03b2\u2010thal patients divided into three groups according to their growth status: (Group 1) 15 with normal growth (N\u2010thal) (Group 2) 16 with decelerated growth (D\u2010thal) and (Group 3) 10 with short stature (S\u2010thal), in order to determine whether GHIS is the cause of their growth retardation.<\/jats:p><\/jats:sec><jats:sec><jats:title>MEASUREMENTS<\/jats:title><jats:p>IGF\u2010I and IGFBP\u20103 were measured daily, before and for 4\u2003days after daily administration of 0\u00b71 IU\/kg hGH, in 3 groups of prepubertal \u03b2\u2010thal patients and normal controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>N\u2010thal and C had similar basal serum IGF\u2010I\u00a0(142\u2003\u00b1\u200352 and 196\u2003\u00b1\u200356\u2003ng\/ml, respectively) and IGFBP\u20103 concentrations (2\u00b707\u2003\u00b1\u20030\u00b749 and 2\u00b766\u2003\u00b1\u20030\u00b741\u2003mg\/l, respectively) as well as a similar percent increase of IGF\u2010I (101\u2003\u00b1\u200323% and 104\u2003\u00b1\u200337%, respectively) and IGFBP\u20103 (52\u2003\u00b1\u200336%, and 38\u2003\u00b1\u200314%, respectively) during the generation tests. S\u2010thal and D\u2010thal had significantly lower basal IGF\u2010I and IGFBP\u20103 concentrations (85\u2003\u00b1\u200342 and 101\u2003\u00b1\u200336\u2003ng\/ml; and 1\u00b760\u2003\u00b1\u20030\u00b749 and 1\u00b779\u2003\u00b1\u20030\u00b752\u2003mg\/l, respectively) as compared to N\u2010thal and C (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b7001 and <jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b7005, respectively), and a significantly higher percent increase of IGF\u2010I and IGFBP\u20103 during the generation tests (249\u2003\u00b1\u200343 and 161\u2003\u00b1\u200376%; and 121\u2003\u00b1\u200399 and 73\u2003\u00b1\u200335%, respectively) as compared to N\u2010thal and C (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b70001 and <jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b701, respectively). Twenty\u2010five percent of the growth retarded patients had classic GH deficiency (GHD) and percent increases of IGF\u2010I and IGFBP\u20103 in the generation tests (164\u2003\u00b1\u200386% and 80\u2003\u00b1\u200349%, respectively) which were similar to those of the remaining growth\u2010retarded children.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The greater percent increases of IGF\u2010I and IGFBP\u20103 in the generation tests of the growth retarded \u03b2\u2010thal patients, both with and without GHD, strongly suggest impaired GH secretion rather than GHIS as the cause of their growth retardation. We conclude that the IGF\u2010I and IGFBP\u20103 generation tests are useful tools for the study not only of GHIS but also of GH secretory disorders in patients with \u03b2\u2010thal and short stature that can easily be performed in an outpatient setting as an initial test to identify the patients that may benefit from GH therapy.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1365-2265.2001.01198.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:47:55Z","timestamp":1047379675000},"page":"253-259","source":"Crossref","is-referenced-by-count":19,"title":["Novel application of IGF\u2010I and IGFBP\u20103 generation tests in the diagnosis of growth hormone axis disturbances in children with \u03b2\u2010thalassaemia"],"prefix":"10.1111","volume":"54","author":[{"given":"Dionisios C.","family":"Chrysis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore 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