{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:46:26Z","timestamp":1762541186118},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,20]],"date-time":"2001-12-20T00:00:00Z","timestamp":1008806400000},"content-version":"vor","delay-in-days":322,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>It has been suggested that the variation of intraocular pressure (IOP<jats:bold>)<\/jats:bold> during the day follows the diurnal variation of serum cortisol. There is also a higher risk of ocular hypertension and\u00a0glaucoma in patients taking excessive oral steroid treatment. We assessed whether different replacement doses of hydrocortisone (HC<jats:bold>)<\/jats:bold> influenced IOP.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Seventeen patients (six Addison's disease, 11 hypopituitarism; seven males<jats:bold>)<\/jats:bold> aged 24\u201358 years mean 42\u00b77 years and 20 control subjects (nine males<jats:bold>)<\/jats:bold> aged 20\u201359 years mean 38\u00b77 years were studied. On the first visit, the 17 patients had been taking HC replacement doses, 20\u2003mg morning and 10\u2003mg afternoon. Serum cortisol and IOP in both eyes (Goldmann applanation tonometer<jats:bold>)<\/jats:bold> were measured at 0900, 1100, 1300, 1500, 1700 hours with HC 20\u2003mg taken after the 0900\u2003h assessment. The dose of HC was then reduced to 10\u2003mg morning and 10\u2003mg afternoon for 1\u2003week and the measurements were repeated in 16 patients, with HC 10\u2003mg taken at 0900\u2003h.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In the patients the peak serum cortisol occurred at 1100\u2003h after the 0900\u2003h HC dose. Cortisol levels were significantly higher at 1100, 1300, 1500 and 1700\u2003h after taking 20\u2003mg compared to 10\u2003mg HC. The mean (SEM<jats:bold>)<\/jats:bold> IOP (mmHg<jats:bold>)<\/jats:bold> was significantly higher after 20\u2003mg HC compared with 10\u2003mg HC at 1300\u2003h: 14\u00b77(0\u00b76<jats:bold>)<\/jats:bold> v 13\u00b71(0\u00b76<jats:bold>) (<\/jats:bold><jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7004<jats:bold>)<\/jats:bold> and at 1500\u2003h: 14\u00b74(0\u00b76<jats:bold>)<\/jats:bold> v 13\u00b71(0\u00b75<jats:bold>) (<\/jats:bold><jats:italic>P<\/jats:italic>\u2003=\u20030\u00b704<jats:bold>)<\/jats:bold>. The total mean (SEM<jats:bold>)<\/jats:bold> daily IOP score was significantly higher after 20\u2003mg HC compared with 10\u2003mg HC: 14\u00b75(0\u00b73<jats:bold>)<\/jats:bold> v 13\u00b75(0\u00b73<jats:bold>) (<\/jats:bold><jats:italic>P<\/jats:italic>\u2003=\u20030\u00b70002<jats:bold>)<\/jats:bold>. The total mean (SEM<jats:bold>)<\/jats:bold> daily IOP score after the 20\u2003mg HC dose compared with the control subjects was: 14\u00b75(0\u00b73<jats:bold>)<\/jats:bold> v 13\u00b77(0\u00b73<jats:bold>) (<\/jats:bold><jats:italic>P<\/jats:italic>\u2003=\u20030\u00b708).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Intraocular pressures during the day are influenced by the morning hydrocortisone replacement dosage with significantly higher intraocular pressure levels in the early afternoon following 20\u2003mg compared with 10\u2003mg. A morning hydrocortisone dose of 10\u2003mg leads to a more physiological intraocular pressure profile during the day. These data support the view that a daily replacement dose of 30\u2003mg hydrocortisone may be excessive.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1365-2265.2001.01200.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:47:55Z","timestamp":1047379675000},"page":"267-271","source":"Crossref","is-referenced-by-count":14,"title":["Hydrocortisone replacement dosage influences intraocular pressure in patients with primary and secondary hypocortisolism"],"prefix":"10.1111","volume":"54","author":[{"given":"J. S. W.","family":"Li Voon Chong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Kyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. A.","family":"MacFarlane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1996.d01-1552.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb02602.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1963.00960050502012"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00682.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6007.448"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1964.tb48212.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.247.14.2002"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-62-5-965"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.76.5.280"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312093292420"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-72-1-39"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1981.tb00634.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(97)03392-8"},{"key":"e_1_2_5_15_1","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1001\/jama.1997.03540330044033","article-title":"Inhaled and nasal glucosteroids and the risks of ocular hypertension or open\u2010angle glaucoma","volume":"277","author":"Garbe E.","year":"1997","journal-title":"Journal of the American Medical Association"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/014107688808100906"},{"key":"e_1_2_5_17_1","first-page":"705","article-title":"The diurnal curve in man: new observations","volume":"12","author":"Henkind P.","year":"1973","journal-title":"Investigative Ophthalmology"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1997.1340955.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(98)00325-0"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1976.tb03801.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1976.tb01274.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(75)90792-8"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006324-197704000-00010"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1997.87897.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199610173351607"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)31039-1"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1997.780907.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0275-5408(97)00036-7"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1972.01000020371001"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1981.03930020665008"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1978.tb01516.x"},{"key":"e_1_2_5_32_1","first-page":"1177","volume-title":"The Glaucomas","author":"Skuta G.L.","year":"1996"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-6374(99)80004-5"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1002056"},{"key":"e_1_2_5_35_1","first-page":"170","article-title":"Acute effects of dexamethasone on intraocular pressure in glaucoma","volume":"26","author":"Weinreb R.N.","year":"1985","journal-title":"Investigative Ophthalmology"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.59.10.566"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00723.x"},{"key":"e_1_2_5_38_1","first-page":"757","article-title":"Diurnal variation in intraocular pressure","volume":"89","author":"Wilensky J.T.","year":"1991","journal-title":"Transactions of the American Ophthalmological Society"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(93)31551-4"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-3-199402010-00005"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2265.2001.01200.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2265.2001.01200.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2265.2001.01200.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T01:19:53Z","timestamp":1697505593000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2265.2001.01200.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["10.1046\/j.1365-2265.2001.01200.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2265.2001.01200.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}