{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T23:10:27Z","timestamp":1724541027812},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,1,12]],"date-time":"2002-01-12T00:00:00Z","timestamp":1010793600000},"content-version":"vor","delay-in-days":256,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:p><jats:bold>OBJECTIVES<\/jats:bold> A possible mechanism for the maintenance of bone mass by oestrogens and the selective oestrogen receptor modulator (SERM)\u2014raloxifene\u2014is an interaction with calciotropic hormones. We studied the effects of raloxifene on calcium\u2010PTH homeostasis.<\/jats:p><jats:p><jats:bold>PATIENTS AND MEASUREMENTS<\/jats:bold> Calcium and EDTA infusions were performed in 32 post\u2010menopausal women with osteoporosis (BMD T score &lt;\u200a\u2212\u20032\u00b75). This cross\u2010sectional study was performed in the third year of the MORE (Multiple Outcomes of Raloxifene Evaluation) trial, a double\u2010blind, placebo\u2010controlled study. After an overnight fast, calcium glubionate (5\u2003mg\/kg BW*h), and after 2\u00b75 h of test\u2010free interval, Na<jats:sub>3<\/jats:sub>EDTA (40\u2003mg\/kg BW*h) were given intravenously. The duration of infusions was based on individual plasma total calcium before the calcium infusion (<jats:italic>t<\/jats:italic>\u2003=\u20030), the target calcium (2\u00b760 and 1\u00b795\u2003mmol\/l, respectively), and desired mean calcium change (0\u00b7010\u2003mmol\/L*min). Blood samples were taken at 0 and every 5\u2003minutes of both infusions. Plasma PTH levels were fitted into an inversed sigmoidal relation with plasma calcium. The effect of raloxifene on calcium\u2010PTH homeostasis was tested in linear regression models adjusted for age and BMI. Nine patients used placebo, 13 raloxifene 60\u2003mg\/day and 10 raloxifene 120\u2003mg\/day.<\/jats:p><jats:p><jats:bold>RESULTS<\/jats:bold> Raloxifene use was associated with lower plasma albumin (40\u00b77\u2003\u00b1\u20031\u00b78 <jats:italic>vs.<\/jats:italic> 38\u00b70\u2003\u00b1\u20032\u00b70 and 38\u00b75\u2003\u00b1\u20032\u00b73\u2003g\/l, for placebo, raloxifene 60\u2003mg\/day and raloxifene 120\u2003mg\/day, respectively, <jats:italic>P<\/jats:italic>\u2003=\u20030\u00b701), lower plasma total calcium at <jats:italic>t<\/jats:italic>\u2003=\u20030 (2\u00b728 <jats:italic>vs.<\/jats:italic> 2\u00b724 and 2\u00b721;\u2003\u00b1\u20030\u00b707\u2003mmol\/L; <jats:italic>P<\/jats:italic>\u2003=\u20030\u00b703), lower plasma total calcium at 50% of maximal PTH secretion (PTH set\u2010point: 2\u00b723\u2003\u00b1\u20030\u00b706 <jats:italic>vs.<\/jats:italic> 2\u00b718\u2003\u00b1\u20030\u00b707 and 2\u00b716\u2003\u00b1\u20030\u00b708 mmol\/l, <jats:italic>P<\/jats:italic>\u2003=\u20030\u00b706), and lower plasma non\u2010suppressible PTH (0\u00b784\u2003\u00b1\u20030\u00b719 <jats:italic>vs.<\/jats:italic> 0\u00b775\u2003\u00b1\u20030\u00b710 and 0\u00b773\u2003\u00b1\u20030\u00b705 pmol\/l, <jats:italic>P<\/jats:italic>\u2003=\u20030\u00b702). After correction for plasma albumin, the differences for plasma calcium at <jats:italic>t<\/jats:italic>\u2003=\u20030 and at PTH set\u2010point were no longer significant. In contrast, the difference in PTH suppression during calcium load was not explained either by differences in plasma albumin or calcium.<\/jats:p><jats:p><jats:bold>CONCLUSION<\/jats:bold> Raloxifene did not have any detectable effect on the PTH set\u2010point. An effect on non\u2010suppressible PTH secretion cannot be excluded.<\/jats:p>","DOI":"10.1046\/j.1365-2265.2001.01263.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:49:29Z","timestamp":1047379769000},"page":"575-582","source":"Crossref","is-referenced-by-count":5,"title":["Effects of the selective oestrogen receptor modulator\u2014raloxifene\u2014on calcium and PTH secretory dynamics in women with osteoporosis"],"prefix":"10.1111","volume":"54","author":[{"given":"A.","family":"Oleksik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Duong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Popp\u2010Snijders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Pliester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Asma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,1,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01623924"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-68-4-831"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-56-3-572"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113915"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-69-3-593"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.4.939"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.23.2189"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199712043372301"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb01918.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-66-3-584"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.7.637"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-102-3-319"},{"key":"e_1_2_6_14_1","first-page":"2151","article-title":"Effects of gonadal suppression on the regulation of parathyroid hormone and 1,25\u2010dihydroxyvitamin D secretion in women. 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