{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:06:41Z","timestamp":1792591601471,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,1,12]],"date-time":"2002-01-12T00:00:00Z","timestamp":1010793600000},"content-version":"vor","delay-in-days":225,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:p><jats:bold>OBJECTIVE<\/jats:bold> Inhibin B is secreted by Sertoli cells in response to FSH and is the major feedback regulator of FSH secretion in man. The serum inhibin B level has emerged as a good marker of spermatogenesis and Sertoli cell function. Varicocele has been associated with infertility and disturbed spermatogenesis. We have studied the effect of varicocele treatment on serum inhibin B levels, with the aim of investigating the effect on spermatogenesis and the involvement of the Sertoli cell in varicocele pathophysiology.<\/jats:p><jats:p><jats:bold>DESIGN AND PATIENTS<\/jats:bold> In a pre\u2013post test design, the effect of varicocele surgery on inhibin B levels was studied in 30 infertile men.<\/jats:p><jats:p><jats:bold>MEASUREMENTS<\/jats:bold> Endocrinology (inhibin B, FSH, LH, SHBG and testosterone) and semen analysis (sperm concentration, motility and morphology).<\/jats:p><jats:p><jats:bold>RESULTS<\/jats:bold> In men receiving varicocele treatment, a significant increase in serum inhibin B levels was observed from 133\u00b79\u2003\u00b1\u200313\u00b74 pretreatment to 167\u00b78\u2003\u00b1\u200316\u00b71\u2003ng\/l after treatment (mean\u2003\u00b1\u2003SEM, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b70001). No significant changes were observed in serum levels of FSH, LH and testosterone. The serum SHBG level decreased from 32\u00b79\u2003\u00b1\u20033\u00b75 to 28\u00b76\u2003\u00b1\u20033\u00b74\u2003nmol\/l (mean\u2003\u00b1\u2003SEM, <jats:italic>P<\/jats:italic>\u2003=\u20030\u00b704) and the free androgen index was significantly increased from 66\u2003\u00b1\u20035\u00b79 pretreatment to 85\u2003\u00b1\u20036\u00b78 after treatment (<jats:italic>P<\/jats:italic>\u2003=\u20030\u00b702, mean\u2003\u00b1\u2003SEM). Semen analysis showed a significant improvement in sperm concentration, from 6\u00b75\u2003\u00b1\u20031\u00b79 pretreatment to 19\u00b73\u2003\u00b1\u20034\u00b79\u2003\u00d7\u200310<jats:sup>6<\/jats:sup>\/ml after treatment (<jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7003, mean\u2003\u00b1\u2003SEM), and in sperm motility from the baseline level of 17\u2003\u00b1\u20033 to 32\u2003\u00b1\u20034% after treatment (<jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7001, mean\u2003\u00b1\u2003SEM).<\/jats:p><jats:p><jats:bold>CONCLUSIONS<\/jats:bold> Varicocele treatment can increase serum inhibin B levels, indicating improvement of spermatogenesis and Sertoli cell function. This finding suggests that the pathophysiology of varicocele involves impairment of Sertoli cell function or a different distribution of germ cell stages.<\/jats:p>","DOI":"10.1046\/j.1365-2265.2001.01302.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:49:24Z","timestamp":1047379764000},"page":"775-780","source":"Crossref","is-referenced-by-count":45,"title":["Increased serum inhibin B levels after varicocele treatment"],"prefix":"10.1111","volume":"54","author":[{"given":"Frank H.","family":"Pierik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salem A\u00eft","family":"Abdesselam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan T. M.","family":"Vreeburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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