{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:44:50Z","timestamp":1773276290756,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,1,12]],"date-time":"2002-01-12T00:00:00Z","timestamp":1010793600000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:p><jats:bold>OBJECTIVES<\/jats:bold> Graves' disease is associated with different human leucocyte antigen (HLA) genes in different populations. This study was designed to examine the HLA class II associations with Graves' disease in Jamaicans.<\/jats:p><jats:p><jats:bold>PATIENTS<\/jats:bold> One hundred and six Jamaicans with Graves' disease and 104 controls.<\/jats:p><jats:p><jats:bold>DESIGN<\/jats:bold> Oligotyping for HLA\u2010DRB1, DRB3, DQA1 and DQB1 alleles was performed using the polymerase chain reaction sequence specific oligonucleotide probe (PCR\u2010SSOP) technique.<\/jats:p><jats:p><jats:bold>RESULTS<\/jats:bold> The frequency of HLA\u2010DRB3 *0101 was increased significantly in the patients compared to controls (38\u00b77% <jats:italic>vs.<\/jats:italic> 19\u00b72%; RR\u2003=\u20032\u00b772; Pc\u2003&lt;\u20030\u00b7015). The protective alleles for Graves' disease were DRB1 *0901 (0\u00b79% <jats:italic>vs.<\/jats:italic> 20\u00b72%; RR\u2003=\u20030\u00b704; Pc\u2003&lt;\u20030\u00b7001), DRB1*1001 (0\u00b70% <jats:italic>vs.<\/jats:italic> 11%; RR\u2003=\u20030\u00b70%; Pc\u2003&lt;\u20030\u00b701) and DRB4 *0101 (0\u00b70% <jats:italic>vs.<\/jats:italic> 12\u00b75%; RR\u2003=\u20030\u00b70; Pc\u2003&lt;\u20030\u00b705). A high female to male ratio of Graves' disease, 25\u2003:\u20031, was observed. Other associated autoimmune diseases were rare and no significant HLA class II associations were found with clinical markers of disease.<\/jats:p><jats:p><jats:bold>CONCLUSIONS<\/jats:bold> Jamaican patients with Graves' disease share the DRB3 *0101 susceptible allele and the DRB4 *01 protective allele but not the susceptible haplotype DRB1 *0301, DRB3 *0101, DQA1 *0501 with Caucasians.<\/jats:p>","DOI":"10.1046\/j.1365-2265.2001.01414.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:52:21Z","timestamp":1047379941000},"page":"805-808","source":"Crossref","is-referenced-by-count":10,"title":["HLA\u2010DRB3 *0101 is associated with Graves' disease in Jamaicans"],"prefix":"10.1111","volume":"55","author":[{"given":"Monica Fisher","family":"Smikle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemarie 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