{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T18:02:22Z","timestamp":1773684142271,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,11,20]],"date-time":"2003-11-20T00:00:00Z","timestamp":1069286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold><jats:sc>objectives<\/jats:sc>\u2002<\/jats:bold> Scintigraphy with radiolabelled octreotide (octreoscan) is useful for imaging various neuroendocrine tumours, especially in patients with midgut carcinoids. We were interested in estimating the efficacy of octreoscan for detection of the primary tumour and metastases in patients with bronchial carcinoids.<\/jats:p><jats:p><jats:bold><jats:sc>patients and methods<\/jats:sc>\u2002<\/jats:bold> Twenty\u2010eight patients with histologically verified bronchial carcinoids underwent octreoscan and the imaging results were compared to CT regarding soft tissue metastases, and to bone scan and MRI regarding bone metastases. The primary tumour had been removed prior to the octreoscan in 12 patients. Metastatic disease was diagnosed in 22 patients.<\/jats:p><jats:p><jats:bold><jats:sc>results<\/jats:sc>\u2002<\/jats:bold> Altogether, 20 patients (71%) had octreoscan\u2010positive tumours, including 2\/5 patients with ectopic ACTH secretion resulting in Cushing's syndrome and 8\/9 patients with carcinoid syndrome. The primary tumour was octreoscan\u2010positive in 13\/16 patients and could be detected on CT in 15\/16 patients. CT failed to localize the primary tumour in one octreoscan\u2010positive patient, presenting with ectopic ACTH secretion and Cushing's syndrome. Intrathoracic recurrences\/metastases were visualized by octreoscan in 7\/9 patients and by CT in 8\/9 patients. CT showed liver metastases in 14 patients; nine of these patients (64%) had octreoscan\u2010positive liver metastases. Ten patients had bone metastases; octreoscan was positive in seven and bone scan in nine of these 10.<\/jats:p><jats:p><jats:bold><jats:sc>conclusions<\/jats:sc>\u2002<\/jats:bold> Octreoscan may be used for follow\u2010up and detection of recurrent disease in patients with somatostatin receptor\u2010positive bronchial carcinoids. In our limited patient material, CT however, seems to be better than octreoscan for visualization of the primary tumour as well as liver metastases.<\/jats:p>","DOI":"10.1046\/j.1365-2265.2003.01931.x","type":"journal-article","created":{"date-parts":[[2003,11,21]],"date-time":"2003-11-21T03:47:46Z","timestamp":1069386466000},"page":"793-799","source":"Crossref","is-referenced-by-count":101,"title":["Octreoscan in patients with bronchial carcinoid tumours"],"prefix":"10.1111","volume":"59","author":[{"given":"Dan","family":"Granberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Sundin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva Tiensuu","family":"Janson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjell","family":"\u00d6berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britt","family":"Skogseid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan\u2010Erik","family":"Westlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,11,20]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1501","article-title":"Receptor scintigraphy with a radioiodinated somatostatin analogue: radiolabeling, purification, biologic activity, and in vivo application in animals","volume":"31","author":"Bakker W.H.","year":"1990","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(91)90052-D"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(96)00078-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.179.4068.77"},{"key":"e_1_2_6_6_1","first-page":"191","article-title":"Imaging of bronchial carcinoid tumors associated to Cushing's syndrome with 111In\u2010Octreoscan scintigraphy and immunoscintigraphy with chromogranin monoclonal antibodies. Report of two cases","volume":"38","author":"Carretta A.","year":"1997","journal-title":"Journal of Cardiovascular Surgery"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199905000-00010"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002590050314"},{"key":"e_1_2_6_9_1","first-page":"42","article-title":"Results and potential of somatostatin receptor imaging in gastroenteropancreatic tract tumours","volume":"44","author":"Chiti A.","year":"2000","journal-title":"Quarterly Journal of Nuclear Medicine"},{"key":"e_1_2_6_10_1","first-page":"5801s","article-title":"Somatostatin receptor scintigraphy in patients with carcinoid tumors: comparison between radioligand uptake and tumor markers","volume":"55","author":"K\u00e4lkner K.\u2010M.","year":"1995","journal-title":"Cancer Research"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.184.4135.482"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.066_c.x"},{"key":"e_1_2_6_13_1","first-page":"1","volume-title":"Nuclear Medicine Annual","author":"Krenning E.P.","year":"1995"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003300050262"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00169802"},{"key":"e_1_2_6_16_1","first-page":"873","article-title":"Octreotide scintigraphy for the detection of paragangliomas","volume":"34","author":"Kwekkeboom D.J.","year":"1993","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002590050297"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-200001000-00006"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1370688"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(98)00075-0"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1994.144"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.1.20"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.79.6.1845"},{"key":"e_1_2_6_24_1","first-page":"224","article-title":"Somatostatin receptor scintigraphy in small\u2010cell lung cancer: results of a multicenter study","volume":"39","author":"Reisinger I.","year":"1998","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910500613"},{"key":"e_1_2_6_26_1","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/0016-5085(93)91066-Q","article-title":"Somatostatin\u2010receptor imaging of neuroendocrine gastroenteropancreatic tumors","volume":"105","author":"Scher\u00fcbl H.","year":"1993","journal-title":"Gastroenterology"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/91.4.295"},{"key":"e_1_2_6_28_1","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1210\/jcem.84.4.5583","article-title":"Usefulness of somatostatin receptor scintigraphy in patients with occult ectopic adrenocorticotropin syndrome","volume":"84","author":"Tabarin A.","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_6_29_1","first-page":"2375","article-title":"Determination of somatostatin receptor subtype 2 in carcinoid tumors by immunohistochemical investigation with somatostatin receptor subtype 2 antibodies","volume":"58","author":"Tiensuu Janson E.","year":"1998","journal-title":"Cancer Research"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.4.1186"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-60049-4_2"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.73.865.737"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-3-199408010-00007"},{"key":"e_1_2_6_34_1","first-page":"367","article-title":"Scintigraphy using a 111Indium\u2013labeled somatostatin analogue for localization of neuroendoccrine tumors","volume":"5","author":"Westlin J.\u2010E.","year":"1992","journal-title":"Antibody, Immunoconjugates and Radiopharmaceuticals"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.1.251"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.6.12.2136"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.2122"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2265.2003.01931.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2265.2003.01931.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2265.2003.01931.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T16:40:34Z","timestamp":1697215234000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2265.2003.01931.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,20]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["10.1046\/j.1365-2265.2003.01931.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2265.2003.01931.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11,20]]}}}