{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T11:04:11Z","timestamp":1748343851029},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T00:00:00Z","timestamp":1223510400000},"content-version":"vor","delay-in-days":2930,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:title>The usefulness of a panel of immunostains in the diagnosis and differentiation of metastatic malignancies in pericardial effusions<\/jats:title><jats:p>Pericardial effusions are not uncommon in patients with an advanced malignancy. Rarely malignancies may present initially with a pericardial effusion. Cytological examination of pericardial fluid may be valuable in differentiation of these cases. However, a metastatic tumour in serous effusion may not always show the functional differentiation of the primary tumour. In such a situation, although a wide range of special studies have been suggested for the diagnosis of malignancy we have found the use of a panel of a few common immunostains to be useful in confirming or suggesting the site of a primary tumour. The material for this study consisted of 76 pericardial fluids obtained between January 1991 and October 1998 from 46 males (mean age 59\u2003years) and 30 females (mean age 52\u2003years). Metastatic malignancy was diagnosed in 22 of the 76 patients and in 7\/22 cases pericardial effusions were the initial presentation. The subsequent follow\u2010up in the seven cases revealed adenocarcinoma of lung (<jats:italic>n<\/jats:italic>\u2003=\u20032), small cell anaplastic carcinoma of lung (<jats:italic>n<\/jats:italic>\u2003=\u20031), squamous cell carcinoma lung (<jats:italic>n<\/jats:italic>\u2003=\u20031), melanoma leg (<jats:italic>n<\/jats:italic>\u2003=\u20031), non\u2010Hodgkin\u2019s lymphoma retroperitoneal lymph nodes (<jats:italic>n<\/jats:italic>\u2003=\u20031) and carcinoma of the breast (<jats:italic>n<\/jats:italic>\u2003=\u20031). Of the remaining 15 cases with a known history of malignancy, eight had cancers (three adeno; two small cell; one poorly differentiated, and two squamous cell types) of the lung; breast (<jats:italic>n<\/jats:italic>\u2003=\u20033); colon (<jats:italic>n<\/jats:italic>\u2003=\u20031); melanoma (<jats:italic>n<\/jats:italic>\u2003=\u20032) and non Hodgkin\u2019s lymphoma (<jats:italic>n<\/jats:italic>\u2003=\u20031). Immunostains which were useful in the diagnosis were EMA, CEA, cytokeratin, B72.3, HMB45, vimentin, S100, LCA, L26 and kappa and lambda light chains.<\/jats:p>","DOI":"10.1046\/j.1365-2303.2000.00260.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T14:00:46Z","timestamp":1047391246000},"page":"312-321","source":"Crossref","is-referenced-by-count":11,"title":["The usefulness of a panel of immunostains in the diagnosis and differentiation of metastatic malignancies in pericardial effusions"],"prefix":"10.1111","volume":"11","author":[{"given":"R. K.","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. N.","family":"Kenwright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Fauck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lallu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Naran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10,9]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"219","article-title":"The distinction of mesothelioma from adenocarcinoma in malignant effusions by electron microscopy.","volume":"29","author":"Kobzik L","year":"1985","journal-title":"Acta Cytol"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840030308"},{"key":"e_1_2_5_4_2","first-page":"125","article-title":"Flow cytometric analysis and cytopatholgy of body cavity fluids.","volume":"31","author":"Stonesifer KJ","year":"1987","journal-title":"Acta Cytol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(84)90211-6"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.81.2.193"},{"key":"e_1_2_5_7_2","first-page":"51","article-title":"Chromosome analysis and cell cytology in effusions: a comparative study.","volume":"58","author":"Hansteen IL","year":"1977","journal-title":"Scand J Respir Dis"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861001)58:7<1479::AID-CNCR2820580717>3.0.CO;2-G"},{"key":"e_1_2_5_9_2","unstructured":"BedrossianCWM.Malignant effusions: a multimodal approach to cytologic diagnosis. 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