{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T05:10:54Z","timestamp":1698642654048},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":571,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We sought to evaluate the parameters of CO<jats:sub>2<\/jats:sub> transport during the administration of acetazolamide in order to assess the role of carbonic anhydrase in CO<jats:sub>2<\/jats:sub> transport.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The partial pressure of carbon dioxide in tissue (<jats:italic>P<\/jats:italic>t\n\t\t\t\t\t<jats:sc>co<\/jats:sc><jats:sub>2<\/jats:sub>), arterial blood (<jats:italic>P<\/jats:italic>a\n\t\t\t\t\t<jats:sc>co<\/jats:sc><jats:sub>2<\/jats:sub>) and end\u2010tidal gas (<jats:italic>P<\/jats:italic>ET\n\t\t\t\t\t<jats:sc>co<\/jats:sc><jats:sub>2<\/jats:sub>) were monitored to study the correlation between <jats:italic>P<\/jats:italic>a\n\t\t\t\t\t<jats:sc>co<\/jats:sc><jats:sub>2<\/jats:sub>, <jats:italic>P<\/jats:italic>t\n\t\t\t\t\t<jats:sc>co<\/jats:sc><jats:sub>2<\/jats:sub> and <jats:italic>P<\/jats:italic>ET\n\t\t\t\t\t<jats:sc>co<\/jats:sc><jats:sub>2<\/jats:sub> in spontaneously breathing healthy volunteers after the intravenous administration of acetazolamide 6\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 60\u2003min after the administration of acetazolamide, the <jats:italic>P<\/jats:italic>t\n\t\t\t\t\t<jats:sc>co<\/jats:sc><jats:sub>2<\/jats:sub> peaked at more than 60\u2003mmHg, and although it decreased by 90\u2003min, it then remained stable above the baseline value. The <jats:italic>P<\/jats:italic>a\n\t\t\t\t\t<jats:sc>co<\/jats:sc><jats:sub>2<\/jats:sub> did not change and the <jats:italic>P<\/jats:italic>ET\n\t\t\t\t\t<jats:sc>co<\/jats:sc><jats:sub>2<\/jats:sub> decreased significantly. The changes in <jats:italic>P<\/jats:italic>t\n\t\t\t\t\t<jats:sc>co<\/jats:sc><jats:sub>2<\/jats:sub> were greater than those of either <jats:italic>P<\/jats:italic>a\n\t\t\t\t\t<jats:sc>co<\/jats:sc><jats:sub>2<\/jats:sub> or <jats:italic>P<\/jats:italic>ET\n\t\t\t\t\t<jats:sc>co<\/jats:sc><jats:sub>2<\/jats:sub>. The minute ventilation increased progressively throughout the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We concluded that gastrotonometry represents a new method for monitoring the dramatic increase in <jats:italic>P<\/jats:italic>t\n\t\t\t\t\t<jats:sc>co<\/jats:sc><jats:sub>2<\/jats:sub> induced by drugs such as acetazolamide clinically, and that it could be a warning against acetazolamide administration in severe patients without keeping a ventilation and circulation reserve.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1365-2362.2000.00663.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T15:48:55Z","timestamp":1047397735000},"page":"501-504","source":"Crossref","is-referenced-by-count":1,"title":["Gastrotonometry represents dramatic increase in <i>P<\/i>c\t\t\t\t\t<scp>o<\/scp><sub>2<\/sub> after acetazolamide administration"],"prefix":"10.1111","volume":"30","author":[{"family":"Taki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Oogushi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Tozuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"253","article-title":"Effect of carbonic anhydrase inhibition on CO2 elimination","volume":"24","author":"Nagai I","year":"1974","journal-title":"Med J Osaka Univ"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.413195"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.55.1.75"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1984.tb12386.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.36.523"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.64.6.422"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1983.tb01946.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00256061"},{"key":"e_1_2_5_10_2","first-page":"884","article-title":"Retention of carbon dioxide in tissue following carbonic anhydrase inhibition in dogs","volume":"15","author":"Taki K","year":"1993","journal-title":"Clin Therap"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1961.16.6.1023"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1980.sp013063"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.66.4.352"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/73.2.225"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.38.445"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(82)90007-5"},{"key":"e_1_2_5_17_2","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0016-5085(83)90016-1","article-title":"Predictive value of intramural pH and other risk factors for massive bleeding from stress ulceration","volume":"85","author":"Fiddian\u2010Green RG","year":"1983","journal-title":"Gastroenterology"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.56.4.1065"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198702000-00015"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2362.2000.00663.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2362.2000.00663.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2362.2000.00663.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T11:16:04Z","timestamp":1698578164000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2362.2000.00663.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["10.1046\/j.1365-2362.2000.00663.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2362.2000.00663.x","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,6]]}}}